Evidence map›Paper›PMID 31443554›Full record

ArticleToxins2019

Evaluation of the Spider (

Tânia C Gonçalves, Pierre Lesport, Sarah Kuylle, Enrico Stura, Justyna Ciolek, Gilles Mourier, Denis Servent, Emmanuel Bourinet, Evelyne Benoit, Nicolas Gilles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Non-Opioid Peptides Targeting Opioid Effects.International journal of molecular sciences · 2021
    Review
  4. Neuroactive venom compounds obtained fromThe journal of venomous animals and toxins including tropical diseases · 2021
    Article
  5. Anti-inflammatory activities of arthropod peptides: a systematic review.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  6. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tânia C GonçalvesService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Pierre LesportInstitut de Génomique Fonctionnelle (IGF), CNRS-UMR 5203, Inserm-U661, Université de Montpellier, Laboratories of Excellence - Ion Channel Science and Therapeutics, F-34094 Montpellier, France.
Sarah KuylleService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Enrico SturaService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Justyna CiolekService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Gilles MourierService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Denis ServentService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France.
Emmanuel BourinetInstitut de Génomique Fonctionnelle (IGF), CNRS-UMR 5203, Inserm-U661, Université de Montpellier, Laboratories of Excellence - Ion Channel Science and Therapeutics, F-34094 Montpellier, France.
Evelyne BenoitService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France. evelyne.benoit@cea.fr.
Nicolas GillesService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France. nicolas.gilles@cea.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the Na

Indexed as

Amino Acid SequenceAnalgesicsAnimalsDisease Models, AnimalDose-Response Relationship, DrugHEK293 CellsHumansMiceNAV1.7 Voltage-Gated Sodium ChannelPainProtein FoldingSpidersSpider VenomsStructure-Activity RelationshipVoltage-Gated Sodium Channel BlockersAnalgesicsNAV1.7 Voltage-Gated Sodium ChannelSpider VenomsVoltage-Gated Sodium Channel Blockershuman voltage-gated ion channel subtypesmouse model of NaV1.7-mediated painNaV1.7 channel subtypePhlogiellus spiderphlotoxin 1

Identifiers

PMID31443554
PMCPMC6784069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.