Evidence map›Paper›PMID 31443482›Full record

ArticleNutrients2019

The Interplay between Maternal and Post-Weaning High-Fat Diet and Gut Microbiota in the Developmental Programming of Hypertension.

Chien-Ning Hsu, Chih-Yao Hou, Chien-Te Lee, Julie Y H Chan, You-Lin Tain

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  10. Article
  11. Maternal High-Fat Diet and Offspring Hypertension.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Gut-brain-bone marrow axis in hypertension.Current opinion in nephrology and hypertension · 2021
    Review
  18. Article
  19. Review
  20. Impact of early-life diet on long-term renal health.Molecular and cellular pediatrics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Chien-Ning HsuDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.ORCID 0000-0001-7470-528X
Chih-Yao HouDepartment of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan.ORCID 0000-0002-8007-6077
Chien-Te LeeDivision of Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Julie Y H ChanInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.ORCID 0000-0001-8036-4645
You-Lin TainInstitute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. tainyl@cgmh.org.tw.
Chang Gung University · TWKaohsiung Chang Gung Memorial Hospital · TWKaohsiung Medical University · TWNational Kaohsiung Marine University · TW

Funding

The Ministry of Science and Technology, Taiwan MOST 107-2314-B-182-045-MY3
6 · The paper itself

Abstract

Excessive intake of saturated fat has been linked to hypertension. Gut microbiota and their metabolites, short-chain fatty acids (SCFAs), are known to be involved in the development of hypertension. We examined whether maternal and post-weaning high-fat (HF) diet-induced hypertension in adult male offspring is related to alterations of gut microbiota, mediation of SCFAs and their receptors, and downregulation of nutrient-sensing signals. Female Sprague-Dawley rats received either a normal diet (ND) or HF diet (D12331, Research Diets) during pregnancy and lactation. Male offspring were put on either the ND or HF diet from weaning to 16 weeks of age, and designated to four groups (maternal diet/post-weaning diet;

Indexed as

Blood PressureDiet, High-FatGastrointestinal MicrobiomePrenatal Exposure Delayed EffectsAge FactorsAMP-Activated Protein KinasesAnimal Nutritional Physiological PhenomenaAnimalsBacteriaDisease Models, AnimalFemaleHypertensionIntestinesKidney CortexMaleMaternal Nutritional Physiological PhenomenaAMP-Activated Protein KinasesGper1 protein, ratPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratReceptors, G-Protein-CoupledReceptors, OdorantAMP-activated protein kinasebutyratedevelopmental origins of health and disease (DOHaD)gut microbiotahigh fat diethypertensionnutrient-sensing signalspropionateshort chain fatty acids

Identifiers

PMID31443482
PMCPMC6769506
OpenAlexW2969443856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.