Evidence map›Paper›PMID 31443474›Full record

ArticleCancers2019

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

Herwig P Moll, Julian Mohrherr, Leander Blaas, Monica Musteanu, Patricia Stiedl, Beatrice Grabner, Katalin Zboray, Margit König, Dagmar Stoiber, Thomas Rülicke and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Herwig P MollDepartment of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6438-9068
Julian MohrherrLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Leander BlaasLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Monica MusteanuLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Patricia StiedlLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Beatrice GrabnerLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Katalin ZborayLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.
Margit KönigChildren's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria.
Dagmar StoiberLudwig Boltzmann Institute for Cancer Research (LBI-CR), 1090 Vienna, Austria.ORCID 0000-0002-8824-0767
Thomas RülickeInstitute of Laboratory Animal, Science, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Sabine StrehlChildren's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria.ORCID 0000-0002-0179-0628
Robert EferlInstitute of Cancer Research, Medical University Vienna & Comprehensive Cancer Center (CCC), 1090 Vienna, Austria.
Emilio CasanovaDepartment of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria. emilio.casanova@meduniwien.ac.at.ORCID 0000-0001-7992-5361
Comprehensive Cancer Center Vienna · ATLudwig Boltzmann Institute for Cancer Research · ATSt Anna Children's Hospital · ATKarolinska Institutet · SESpanish National Cancer Research Centre · ESUniversity of Veterinary Medicine Vienna · AT

Funding

Austrian Science Fund P 25599Austrian Science Fund P25925Austrian Science Fund P26908Austrian Science Fund P29222Austrian Science Fund FWF P 25599Austrian Science Fund FWF P 25925
6 · The paper itself

Abstract

Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors.

Indexed as

bacterial artificial chromosomeCre/loxPembryonic stem cellsgene targetingliver steatosisrecombineering

Identifiers

PMID31443474
PMCPMC6770775
OpenAlexW2969751272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.