ArticleJournal of clinical medicine2019
The Relationship between Metabolically Healthy Obesity and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association between metabolic syndrome and myocardial infarction among patients with excess body weight: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Medical Nutrition Therapy Interventions Provided by Dietitians for Adult Overweight and Obesity Management: An Academy of Nutrition and Dietetics Evidence-Based Practice Guideline.Journal of the Academy of Nutrition and Dietetics · 2023Guideline
- Association Between Obesity and Cardiovascular Outcomes: Updated Evidence from Meta-analysis Studies.Current cardiology reports · 2020Pooled it
- The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Evaluation of Serum Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels in Different Metabolic Obesity Phenotypes and Their Association with Inflammatory Cytokines: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Metabolically healthy obesity is independently associated with 20-year incidence of cardiovascular disease: findings from the ATTICA cohort study (2002-2022).International journal of obesity (2005) · 2026Article
- Dynamic associations of BMI-metabolic phenotype transitions with incident cardiovascular disease in middle-aged and elderly adults: a longitudinal cohort study.BMC cardiovascular disorders · 2026Article
- Sex- and age-specific associations between metabolic phenotypes and brachial-ankle pulse wave velocity in adults: a cross-sectional study.Frontiers in medicine · 2026Article
- Unlocking the power of semen analysis in primary health care - a path to men's health and lifestyle transformation.Nature reviews. Urology · 2025Review
- Impact of Metabolically Healthy Obesity on Cardiovascular Outcomes in Older Adults with HFpEF: Insights from a Nationwide Sample.Journal of clinical medicine · 2025Article
- A Longitudinal Cohort Assessing the Carotid Intima-Media Thickness Progression and Cardiovascular Risk Factors in a Rural Black South African Community.Journal of clinical medicine · 2025Article
- Metabolic obesity phenotypes and risk of ischemic stroke: The Rural Chinese Cohort Study.Frontiers in nutrition · 2025Article
- Type 2 diabetes prediction without labs: a systems-level neural framework for risk and behavioral network reorganization.Frontiers in digital health · 2025Article
- Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications.Nature reviews. Endocrinology · 2024Review
- Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study.Cardiovascular diabetology · 2024Article
- Obesity and metabolic syndrome in patients with heart failure with preserved ejection fraction: a cross-sectional analysis of the Veradigm Cardiology Registry.BMC endocrine disorders · 2024Article
- Metabolically healthy obesity and health risks - a review of meta-analyses.Central European journal of public health · 2024Review
- U-shaped association between the triglyceride-glucose index and atrial fibrillation incidence in a general population without known cardiovascular disease.Cardiovascular diabetology · 2023Article
- Association of body mass index, metabolic health status and clinical outcomes in acute myocardial infarction patients: a national registry-based study.Frontiers in cardiovascular medicine · 2023Article
- Normal-weight central obesity: implications for diabetes mellitus.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) risk in individuals with metabolically healthy obesity (MHO) is unclear. We searched databases from inception to May 2019. Data were pooled using a random effects model. Newcastle-Ottawa Scale assessment was performed. Primary and secondary outcomes were CVD risk and all-cause mortality. Forty-three studies involving 4,822,205 cases were included. The median percentage of females, age and duration of follow-up was 52%, 49.9 years and 10.6 years, respectively. The mean Newcastle-Ottawa Scale score of the articles was 7.9 ± 1.0. Compared to individuals with a metabolically healthy normal weight, individuals with MHO had higher adjusted risk of CVD and all-cause mortality. We identified a significant linear dose-response relationship between body mass index (BMI) and CVD risk among metabolically healthy individuals (
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