ArticleCells2019
Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection.
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Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- High concordance in plasma and CSF HIV-1 drug resistance mutations despite high cases of CSF viral escape in individuals with HIV-associated cryptococcal meningitis in Botswana.The Journal of antimicrobial chemotherapy · 2022Trial
- HIV-1 compartmentalization in the central nervous system during cryptococcal meningitis: Analysis of viral, fungal, and host factors.PLoS pathogens · 2026Article
- Ultrasensitive single-genome sequencing reveals strong purifying selection in acute HIV-1 infection.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection.Frontiers in immunology · 2025Article
- BonoboFlow: viral genome assembly and haplotype reconstruction from nanopore reads.Bioinformatics advances · 2025Article
- Central Nervous System Effects of Early HIV Infection and Consequences of Antiretroviral Therapy Initiation during Acute HIV.Viruses · 2024Review
- Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging.The Journal of infectious diseases · 2023Article
- Immunological, Cognitive, and Psychiatric Outcomes After Initiating Efavirenz- and Dolutegravir-based Antiretroviral Therapy During Acute Human Immunodeficiency Virus Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection.Seminars in immunopathology · 2022Review
- HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies.Current HIV/AIDS reports · 2022Review
- Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection.PLoS pathogens · 2021Article
- Article
- Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae.Viruses · 2021Review
- Review
- Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Article
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Authors and funding
34 authors at 6 institutions in 4 countries.
Sodsai TovanabutraU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. stovanabutra@hivresearch.org.
Rujipas SirijatuphatU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Phuc T PhamU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Lydia BonarU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Elizabeth A HarbolickU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Meera BoseU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Hongshuo SongU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
David ChangU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Celina OropezaU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Anne Marie O'SullivanU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Joyce BalinangU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Eugene KroonSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Donn J ColbySEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Carlo SacdalanSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Joanna HellmuthMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Phillip ChanSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.ORCID 0000-0002-4071-4409
Peeriya PrueksakaewSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Suteeraporn PinyakornU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Linda L JagodzinskiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Duanghathai SutthichomSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Suwanna PattamaswinSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Mark de SouzaThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Robert A GramzinskiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Jerome H KimU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Nelson L MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-3949-9649
Nittaya PhanuphakSEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Jintanat AnanworanichU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Victor ValcourMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Gustavo H KijakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Eric Sanders-BuellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Serena SpudichDepartment of Neurology, Yale University; New Haven, CT 06510, USA.
MHRP Viral Sequencing Core
RV254/SEARCH 010 Study Team
Henry M. Jackson Foundation · USThai Red Cross Society · THUniversity of California, San Francisco · USWalter Reed Army Institute of Research · USInternational Vaccine Institute · KRYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MMultidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4MLong-Term CNS Consequences of Treatment During Acute InfectionR01MH095613 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPUDICH, SERENA S, VALCOUR, VICTOR · 2011 to 2015
$3.1MTherapeutic Interventions during Acute Infection to Address the CNS Reservoir forR01NS084911 · NINDS · YALE UNIVERSITY · PI ANANWORANICH, JINTANAT, SPUDICH, SERENA S · 2013 to 2017
$2.3MNCATS NIH HHS UL1 TR001863NIA NIH HHS P01 AG019724NIA NIH HHS T32 AG023481NIMH NIH HHS R01 MH095613NINDS NIH HHS R01 NS084911
Abstract
HIV-1 disseminates to a broad range of tissue compartments during acute HIV-1 infection (AHI). The central nervous system (CNS) can serve as an early and persistent site of viral replication, which poses a potential challenge for HIV-1 remission strategies that target the HIV reservoir. CNS compartmentalization is a key feature of HIV-1 neuropathogenesis. Thus far, the timing of how early CNS compartmentalization develops after infection is unknown. We examined whether HIV-1 transmitted/founder (T/F) viruses differ between CNS and blood during AHI using single-genome sequencing of envelope gene and further examined subregions in
Indexed as
HIV-1HIV InfectionsAdultFemaleGenes, envGenes, polHigh-Throughput Nucleotide SequencingHumansMaleRNA, ViralSequence Analysis, RNAVirus ReplicationYoung AdultRNA, Viralacute HIV-1 infection (AHI)central nervous system (CNS)cerebrospinal fluid (CSF)compartmentalizationHIV-1multiple infectionsnext-generation sequencing (NGS)single-genome amplification (SGA)transmitted/founder (T/F) virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.