ArticleNutrients2019
Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Metabolic syndrome in relation to dietary acid load: a dose-response meta-analysis of observational studies.Frontiers in nutrition · 2023Pooled it
- Association between dietary acid load and cancer risk and prognosis: An updated systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2022Pooled it
- Hemoglobin A1c Levels Modify Associations between Dietary Acid Load and Breast Cancer Recurrence.Nutrients · 2020Trial
- Dietary acid load and oxidative stress in relation to sleep quality and duration among Iranian adults.Scientific reports · 2026Article
- The association between dietary acid load and endometriosis: a case-control study.BMC women's health · 2026Article
- Dietary Acid Load, Empirical Dietary Inflammatory Index, and Literature-Based Adherence to Mediterranean Diet Score Relationship With Primary Dysmenorrhea.Food science & nutrition · 2026Article
- Methionine Intake, Dietary Acid Load, and Breast Cancer Risk: A Case-control Study.Journal of cancer prevention · 2026Article
- Promoting Re-Epithelialization in Diabetic Foot Wounds Using Integrative Therapeutic Approaches.Bioengineering (Basel, Switzerland) · 2025Article
- Dietary acid load and its association with psychological disorders, sleep quality, and mood among Iranian older adults: a cross-sectional study.BMC public health · 2025Article
- The association between dietary acid load and risk of gallstone: a case-control study.Journal of health, population, and nutrition · 2025Article
- Dietary acid load and the odds of knee osteoarthritis: a case-control study.Scientific reports · 2025Article
- Association of dietary acid load with inflammatory markers, oxidative stress, and clinical features in patients with knee osteoarthritis.Scientific reports · 2025Article
- Dietary acid load adopts the effect of ApoB ins/del genetic variant (rs11279109) on obesity trait, cardiovascular markers, lipid profile, and serum leptin level among patients with diabetes: a cross-sectional study.Scientific reports · 2024Article
- Assessing the role of dietary acid load in the development of hypertensive disorders during pregnancy: uncovering the association through prospective cohort analysis.Nutrition journal · 2024Article
- Glymphatic function and its influencing factors in different glucose metabolism states.World journal of diabetes · 2024Article
- Effects of Alterations in Acid-Base Effects on Insulin Signaling.International journal of molecular sciences · 2024Review
- Dietary acid load and markers of malnutrition, inflammation, and oxidative stress in hemodialysis patients.Frontiers in nutrition · 2024Article
- Animal protein intake is directly associated with serum level of pentraxin 3 in hemodialysis patients.Scientific reports · 2023Article
- A Scoping Review to Explore the Potential Benefits of Nutrition Interventions for Latino/a Adult Cancer Survivors in the US.Nutrients · 2023Article
- Association between dietary acid load and the odds of ulcerative colitis: a case-control study.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Metabolic acidosis can lead to inflammation, tissue damage, and cancer metastasis. Dietary acid load contributes to metabolic acidosis if endogenous acid-base balance is not properly regulated. Breast cancer survivors have reduced capacities to adjust their acid-base balance; yet, the associations between dietary acid load and inflammation and hyperglycemia have not been examined among them. We analyzed data collected from 3042 breast cancer survivors enrolled in the Women's Healthy Eating and Living (WHEL) Study who had provided detailed dietary intakes and measurements of plasma C-reactive protein (CRP) and hemoglobin A1c (HbA1c). Using a cross-sectional design, we found positive associations between dietary acid load and plasma CRP and HbA1c. In the multivariable-adjusted models, compared to women with the lowest quartile, the intakes of dietary acid load among women with the highest quartile showed 30-33% increases of CRP and 6-9% increases of HbA1c. Our study is the first to demonstrate positive associations between dietary acid load and CRP and HbA1c in breast cancer survivors. Our study identifies a novel dietary factor that may lead to inflammation and hyperglycemia, both of which are strong risk factors for breast cancer recurrence and comorbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.