Evidence map›Paper›PMID 31443222›Full record

ReviewMedicina (Kaunas, Lithuania)2019

Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases.

Paulina Korta, Ewa Pocheć, Agnieszka Mazur-Biały

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06699069 (The Effect of Exercise on Serum Irisin Levels in Hypothyroid Sprague Dawley Rats), which is not on this map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06699069 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Exercise on Serum Irisin Levels in Hypothyroid Sprague Dawley Rats

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled30ConditionsHypothyroidismArmsControl or Euthyroid group, Hypothyroid group, Hypothyroid group received exercise
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Paulina KortaDepartment of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland.ORCID 0000-0002-3165-5259
Ewa PochećDepartment of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland. ewa.pochec@uj.edu.pl.ORCID 0000-0002-9113-8579
Agnieszka Mazur-BiałyDepartment of Ergonomics and Exercise Physiology, Faculty of Health Sciences, Jagiellonian University, Medical College, Grzegorzecka 20, 31-531 Krakow, Poland.ORCID 0000-0003-1056-8276
Jagiellonian University · PL

Funding

Jagiellonian University N43/DBS/000047 and K/ZDS/008062
6 · The paper itself

Abstract

Sedentary life style is considered to be an independent risk factor for many disorders, including development of type 2 diabetes, obesity, immune dysfunction, asthma, and neurological or coronary heart disease. Irisin is released from myocytes during physical activity, and acts as a link between muscles and other tissues and organs. This myokine is produced as a result of proteolytic cleavage of FNDC5 protein present in the membrane of myocytes. Secretion of irisin is regulated by

Indexed as

Adipose TissueExerciseFibronectinsGlycosylationHumansInflammationMuscle CellsObesityFibronectinsFNDC5 protein, humancancersFNDC5inflammationirisinN-glycosylationobesityphysical activity

Identifiers

PMID31443222
PMCPMC6722973
OpenAlexW2967376260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.