Evidence map›Paper›PMID 31442840›Full record

ArticleCell calcium2019

The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells.

Timnit Yosef Asfaha, Gihan S Gunaratne, Malcolm E Johns, Jonathan S Marchant, Timothy F Walseth, James T Slama

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Endo-Lysosomal Two-Pore Channels and Their Protein Partners.Handbook of experimental pharmacology · 2023
    Review
  3. NAADP-Evoked CaHandbook of experimental pharmacology · 2023
    Article
  4. NAADP-binding proteins find their identity.Trends in biochemical sciences · 2022
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Timnit Yosef AsfahaDepartment of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, OH, 43614, United States.
Gihan S GunaratneDepartment of Pharmacology, University of Minnesota Medical School, 312 Church St., Minneapolis, MN, 55455-0217, United States.
Malcolm E JohnsDepartment of Pharmacology, University of Minnesota Medical School, 312 Church St., Minneapolis, MN, 55455-0217, United States.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226-0509, United States.
Timothy F WalsethDepartment of Pharmacology, University of Minnesota Medical School, 312 Church St., Minneapolis, MN, 55455-0217, United States. Electronic address: walse001@umn.edu.
James T SlamaDepartment of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, OH, 43614, United States. Electronic address: james.slama@utoledo.edu.
University of Minnesota Medical Center · USUniversity of Toledo · USMedical College of Wisconsin · US

Funding

Functional architecture of IP3-evoked local Ca2+ signalsR01GM088790 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S, SLAMA, JAMES T · 2009 to 2025
$4.7M
Identification of the Elusive NAADP ReceptorR15GM131329 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SLAMA, JAMES T · 2018 to 2018
$462k
Chemobiologic Approach to NAADP SignalingR15GM100444 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SLAMA, JAMES T · 2012 to 2012
$351k
NIGMS NIH HHS R01 GM088790NIGMS NIH HHS R15 GM100444NIGMS NIH HHS R15 GM131329
6 · The paper itself

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca

Indexed as

AnimalsBenzoic AcidBinding SitesCalciumCalcium SignalingCell Line, TumorClick ChemistryHumansNADPPhotoaffinity LabelsProtein BindingSea UrchinsBenzoic AcidCalciumNAADPNADPPhotoaffinity LabelsCalcium intracellular releaseChemical biologyClick chemistryNucleoside/nucleotide analoguePhotoaffinity labelingReceptorSea urchinSecond messenger

Identifiers

PMID31442840
PMCPMC6774857
OpenAlexW2965750663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.