Evidence map›Paper›PMID 31442558›Full record

ArticleMagnetic resonance imaging2019

Measurement of murine kidney functional biomarkers using DCE-MRI: A multi-slice TRICKS technique and semi-automated image processing algorithm.

Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. MRI of kidney size matters.Magma (New York, N.Y.) · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kai JiangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Hui TangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Prasanna K MishraDivision of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Slobodan I MacuraDivision of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA. Electronic address: Lerman.Lilach@mayo.edu.

Funding

Ultrasound Shockwave Therapy for Post-Stenotic Microvascular RemodelingR01HL123160 · NHLBI · MAYO CLINIC ROCHESTER · PI LERMAN, AMIR, LERMAN, LILACH O · 2015 to 2018
$3.0M
MSC-derived microvesicles in metabolic syndrome and renovascular diseaseR01DK102325 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2015 to 2018
$2.8M
Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6M
Noninvasive assessment of renal fibrosis using magnetization transfer MRIU01DK104273 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2014 to 2018
$1.8M
NHLBI NIH HHS R01 HL123160NIDDK NIH HHS R01 DK102325NIDDK NIH HHS R01 DK120292NIDDK NIH HHS U01 DK104273
6 · The paper itself

Abstract

purposeTo propose a rapid multi-slice T

methodsA multi-slice TRICKS sampling scheme was implemented in an established rapid T

resultsThe TRICKS sampling scheme achieved an acceleration factor of 2.7, allowing imaging of eight axial slices at 1.23 s/scan. With the aid of the semi-automated scheme, image analysis required under 15-min for both kidneys per mouse. The multi-slice technique yielded renal perfusion and GFR values comparable to the single-slice technique. Model-fitted renal parameters successfully differentiated control and stenotic mouse kidneys, including renal perfusion (706.5 ± 164.0 vs. 375.9 ± 277.9 mL/100 g/min, P = 0.002), blood flow (1.6 ± 0.4 vs. 0.7 ± 0.7 mL/min, P < 0.001), and GFR (142.9 ± 17.9 vs. 58.0 ± 42.8 μL/min, P < 0.001).

conclusionThe multi-slice TRICKS-based DCE-MRI technique, with a semi-automated image processing scheme, allows rapid and comprehensive measurement of murine kidney function.

Indexed as

Kidney Function TestsMagnetic Resonance ImagingPattern Recognition, AutomatedAlgorithmsAnimalsBiomarkersContrast MediaGlomerular Filtration RateImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedKidneyKineticsMaleMiceMice, Inbred C57BLRenal Artery ObstructionBiomarkersContrast MediaDynamic contrast enhanced MRIKidney volumeMachine learningRenal functional biomarkersTime-resolved imaging of contrast kinetics

Identifiers

PMID31442558
PMCPMC6861697

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.