Evidence map›Paper›PMID 31442546›Full record

ReviewMolecular and cellular endocrinology2019

Endoplasmic reticulum quality control in lipoprotein metabolism.

Cari M Koerner, Benjamin S Roberts, Saskia B Neher

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular and cellular endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease.Cellular and molecular gastroenterology and hepatology · 2025
    Review
  4. Total alkaloids fromFrontiers in pharmacology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Review
  14. Review
  15. Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cari M KoernerDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, USA.
Benjamin S RobertsDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, USA.
Saskia B NeherDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, USA. Electronic address: neher@email.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Investigation of the Molecular Mechanisms of Lipoprotein Lipase InhibitorsR01HL125654 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NEHER, SASKIA · 2015 to 2024
$3.8M
NHLBI NIH HHS R01 HL125654
6 · The paper itself

Abstract

Lipids play a critical role in energy metabolism, and a suite of proteins is required to deliver lipids to tissues. Several of these proteins require an intricate endoplasmic reticulum (ER) quality control (QC) system and unique secondary chaperones for folding. Key examples include apolipoprotein B (apoB), which is the primary scaffold for many lipoproteins, dimeric lipases, which hydrolyze triglycerides from circulating lipoproteins, and the low-density lipoprotein receptor (LDLR), which clears cholesterol-rich lipoproteins from the circulation. ApoB requires specialized proteins for lipidation, dimeric lipases lipoprotein lipase (LPL) and hepatic lipase (HL) require a transmembrane maturation factor for secretion, and the LDLR requires several specialized, domain-specific chaperones. Deleterious mutations in these proteins or their chaperones may result in dyslipidemias, which are detrimental to human health. Here, we review the ER quality control systems that ensure secretion of apoB, LPL, HL, and LDLR with a focus on the specialized chaperones required by each protein.

Indexed as

Apolipoproteins BCholesterolEndoplasmic ReticulumHumansLipidsLipoprotein LipaseLipoproteinsMolecular ChaperonesQuality ControlReceptors, LDLApolipoproteins BCholesterolLDLR protein, humanLipidslipoprotein cholesterolLipoprotein LipaseLipoproteinsMolecular ChaperonesReceptors, LDLER quality controlHLLDLRLipid metabolismLipoproteinLPL

Identifiers

PMID31442546
PMCPMC6814580
OpenAlexW2969545282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.