ArticleCell2019
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.
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Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers.
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227citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
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Who cites it
227 citing papers in PubMed, 368 citations in OpenAlex.
- Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia.Frontiers of medicine · 2022Trial
- Trial
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.bioRxiv : the preprint server for biology · 2026Article
- Intestinal epithelial memory: from inflammatory imprinting to metabolite-shaped immune tolerance.Barrier immunity · 2026Article
- Dietary Regulation of Intestinal Stem Cell Function: Nutrient-Sensing, Microbiota-Mediated, and Regenerative Mechanisms from a Dietetic Perspective.Biomedicines · 2026Review
- Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma.Nature communications · 2026Article
- Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis.Cell stem cell · 2026Article
- Article
- An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.Nature immunology · 2026Article
- Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation.Experimental & molecular medicine · 2026Article
- Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility.Cell · 2026Article
- Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine-Induced Kidney Injury via OXCT1-Mediated Ketolysis in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- A selective and augmentable butyrate-FFAR2 signal circuitry programs the cellular identity of enteroendocrine L-cells.Communications biology · 2026Article
- O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells.bioRxiv : the preprint server for biology · 2026Article
- The Role of Antioxidants in the Connection Between Microbiota, Neuroinflammation and Epilepsy.Biomedicines · 2026Review
- Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and attenuate cell senescence.Cell death & disease · 2026Article
- A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program.Nature communications · 2026Article
- Diet-induced chromatin states influence intestinal stem cell memory.bioRxiv : the preprint server for biology · 2026Article
- TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.Cell death & disease · 2026Article
167 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 11 institutions in 3 countries.
Chia-Wei ChengKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Moshe BitonDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Adam L HaberKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Nuray GunduzKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University, 06800 Ankara, Turkey.
George EngKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.
Liam T GaynorDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
Surya TripathiKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Gizem Calibasi-KocalKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey.
Steffen RickeltKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Vincent L ButtyBioMicro Center at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.
Marta Moreno-SerranoKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Ameena M IqbalKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Khristian E Bauer-RoweKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Shinya ImadaKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Mehmet Sefa UlutasKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, Siirt University, Science and Arts Faculty, 56100 Siirt, Turkey.
Constantine MylonasDepartment of Biology, MIT, Cambridge, MA 02139, USA.
Mark T WharyDivision of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
Stuart S LevineBioMicro Center at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.
Yasemin BasbinarDokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey.
Richard O HynesKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.
Vikram DeshpandeDepartment of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.
Laurie A BoyerDepartment of Biology, MIT, Cambridge, MA 02139, USA.
James G FoxDivision of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
Christopher TerranovaGenomic Medicine Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kunal RaiGenomic Medicine Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Helen Piwnica-WormsDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Maria M MihaylovaDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210 USA.
Aviv RegevKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.
Ömer H YilmazKoch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ohyilmaz@mit.edu.
Allen Institute · USKoch Institute for Integrative Cancer Research At MITIIT@MIT · USBroad Institute · USThe University of Texas MD Anderson Cancer Center · USDokuz Eylül University · TRMassachusetts General Hospital · USDana-Farber Cancer Institute · USHarvard University · USHoward Hughes Medical Institute · USThe Ohio State University · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3MMOLECULAR IMMUNOLOGY AND TUMOR BIOLOGYT32CA009216 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Michael Langenau · 1985 to 2026
$10.6MUnderstanding and Improving Platinum Anticancer DrugsR01CA034992 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 1985 to 2018
$6.8MProject 2U54CA224068 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CORCORAN, RYAN BRUCE, FLAHERTY, KEITH T · 2017 to 2021
$6.3MThe Extracellular Matrix in Tumor Progression and MetastasisU54CA163109 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEINBERG, ROBERT A · 2011 to 2015
$3.7MFasting Protects Small Intestinal Stem Cells from Lethal DNA Damage: Mechanistic Insight and Preclinical TranslationR01CA207236 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PIWNICA-WORMS, HELEN M · 2017 to 2021
$2.4MDietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0MUnderstanding the Mechanisms of Age-Dependent Decline of Intestinal Stem Cell FunctionR00AG054760 · NIA · OHIO STATE UNIVERSITY · PI MIHAYLOVA, MARIA M. · 2018 to 2020
$747kRegulation of the Intestinal Stem Cell Niche in AgingR00AG045144 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2014 to 2016
$740kElucidating the role of fasting in intestinal stemness and tissue regenerationR00DK123407 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHENG, CHIA-WEI · 2021 to 2023
$727kUnderstanding the Mechanisms of Age-Dependent Decline of Intestinal Stem Cell FunctionK99AG054760 · NIA · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI MIHAYLOVA, MARIA M. · 2017 to 2018
$224kElucidating the role of fasting in intestinal stemness and tissue regenerationK99DK123407 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHENG, CHIA-WEI · 2019 to 2020
$182kHoward Hughes Medical InstituteNCI NIH HHS R01 CA034992NCI NIH HHS R01 CA207236NCI NIH HHS R01 CA211184NCI NIH HHS T32 CA009216NCI NIH HHS U54 CA163109NCI NIH HHS U54 CA224068NIA NIH HHS K99 AG054760NIA NIH HHS R00 AG045144NIA NIH HHS R00 AG054760NIDDK NIH HHS K99 DK123407NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R00 DK123407
Abstract
Little is known about how metabolites couple tissue-specific stem cell function with physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies, including beta-hydroxybutyrate (βOHB), distinguishes self-renewing Lgr5
Indexed as
Diet, High-Fat3-Hydroxybutyric AcidAged, 80 and overAnimalsCell DifferentiationCell Self RenewalFemaleHistone Deacetylase InhibitorsHumansHydroxymethylglutaryl-CoA SynthaseIntestinesKetone BodiesMaleMiceMice, KnockoutReceptors, G-Protein-Coupled3-Hydroxybutyric AcidHistone Deacetylase InhibitorsHMGCS2 protein, mouseHydroxymethylglutaryl-CoA SynthaseKetone BodiesLgr5 protein, mouseReceptors, G-Protein-CoupledReceptors, Notchbeta-hydroxybutyrateHDACHmgcs2Intestinal stem cellketogenic dietketone bodiesNotch
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