Evidence map›Paper›PMID 31442403›Full record

ArticleCell2019

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

Stefan Jordan, Navpreet Tung, Maria Casanova-Acebes, Christie Chang, Claudia Cantoni, Dachuan Zhang, Theresa H Wirtz, Shruti Naik, Samuel A Rose, Chad N Brocker and 17 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04271748 (The Impact of Time Restricted Feeding in Crohn's Disease), which is not on this map. Cited by 247 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
247citing papers in PubMed, 1 pooled it
25.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04271748 nacompletednot on this mapstarted 2021, after this paper: background citation

The Impact of Time Restricted Feeding in Crohn's Disease

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2021 to 2022Enrolled15ConditionsCrohn's Disease (CD)ArmsTime Restricted Feeding
3 · Its place in the literature

Who cites it

247 citing papers in PubMed, 1 synthesis or guideline pooled it, 433 citations in OpenAlex.

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187 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 4 countries.

Stefan JordanDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: stefan.jordan@mssm.edu.
Navpreet TungDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Maria Casanova-AcebesDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Christie ChangDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Claudia CantoniDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St. Louis, MO 63110, USA.
Dachuan ZhangRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, The Bronx, NY 10461, USA.
Theresa H WirtzDepartment of Internal Medicine III, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Shruti NaikDepartment of Pathology, and Ronald O. Perelman Department of Dermatology, NYU School of Medicine, 240 East 38(th) Street, New York, NY 10016, USA.
Samuel A RoseDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Chad N BrockerLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Bethesda, MD 20892, USA.
Anastasiia GainullinaDepartment of Pathology & Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Computer Technologies Department, ITMO University, Kronverksky 49, Saint Petersburg, Russian Federation.
Daniel HornburgMax-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Sam HorngDepartment of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Barbara B MaierDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Paolo CravediThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Derek LeRoithDivision of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Bethesda, MD 20892, USA.
Felix MeissnerMax-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Jordi OchandoDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Adeeb RahmanThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Jerry E ChipukDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Maxim N ArtyomovDepartment of Pathology & Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Paul S FrenetteRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Cell Biology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, The Bronx, NY 10461, USA.
Laura PiccioDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St. Louis, MO 63110, USA; Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown NSW 2050, Australia.
Marie-Luise BerresDepartment of Internal Medicine III, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Emily J GallagherDivision of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Miriam MeradDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: miriam.merad@mssm.edu.
Icahn School of Medicine at Mount Sinai · USAlbert Einstein College of Medicine · USMax Planck Institute of Biochemistry · DENational Institutes of Health · USRWTH Aachen University · DEWashington University in St. Louis · USITMO University · RUNew York University · USThe University of Sydney · AU

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4M
ERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0M
Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disesaseU24AI118644 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERIN, CECILIA, MERAD, MIRIAM · 2015 to 2020
$2.4M
Intermittent Fasting-induced Gut Microbiome Modulation of CNS AutoimmunityR01NS102633 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHOU, YANJIAO · 2017 to 2022
$2.1M
Obesity and triple negative breast cancer; the role of hypercholesterolemiaR01CA200553 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEROITH, DEREK · 2016 to 2020
$1.9M
Cholesterol promotes breast cancer progression: establishing the mechanismsK08CA190770 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GALLAGHER, EMILY JANE · 2014 to 2018
$843k
NCI NIH HHS K08 CA190770NCI NIH HHS R01 CA154947NCI NIH HHS R01 CA200553NIAID NIH HHS U19 AI128949NIAID NIH HHS U24 AI118644NIDDK NIH HHS P30 DK056341NINDS NIH HHS R01 NS102633
6 · The paper itself

Abstract

Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes. Regulation of peripheral monocyte numbers was dependent on dietary glucose and protein levels. Specifically, we found that activation of the low-energy sensor 5'-AMP-activated protein kinase (AMPK) in hepatocytes and suppression of systemic CCL2 production by peroxisome proliferator-activator receptor alpha (PPARα) reduced monocyte mobilization from the bone marrow. Importantly, we show that fasting improves chronic inflammatory diseases without compromising monocyte emergency mobilization during acute infectious inflammation and tissue repair. These results reveal that caloric intake and liver energy sensors dictate the blood and tissue immune tone and link dietary habits to inflammatory disease outcome.

Indexed as

Caloric RestrictionAdultAMP-Activated Protein KinasesAnimalsAntigens, LyBone Marrow CellsChemokine CCL2FemaleHepatocytesHumansInflammationMaleMiceMice, Inbred C57BLMice, KnockoutMonocytesAMP-Activated Protein KinasesAntigens, LyChemokine CCL2PPAR alphaAMPKCaloric restrictionCCL2fastinginflammationinflammatory diseaselivermetabolismmonocytePPARα

Identifiers

PMID31442403
PMCPMC7357241
OpenAlexW2969628442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.