ArticleCell2019
Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic.
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Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
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Who cites it
62 citing papers in PubMed.
- Uridine and pyruvate supplementation is associated with Th1 polarization during mitotoxic antibiotic therapy.iScience · 2026Article
- Revealing the hidden burden: wastewater-based epidemiology for underreported and emerging infectious diseases in communities.Environmental monitoring and assessment · 2026Review
- Parallel algorithms for phylogenetic inference under a structured coalescent approximation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.Cell reports · 2026Article
- Biological causes and impacts of rugged tree landscapes in phylodynamic inference.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cryptic Circulation and Co-Infections of Endemic Human Coronaviruses During the First Years of the COVID-19 Pandemic in Brazil.Advances in respiratory medicine · 2025Article
- Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.medRxiv : the preprint server for health sciences · 2025Article
- Parallel algorithms for phylogenetic inference under a structured coalescent approximation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Biological causes and impacts of rugged tree landscapes in phylodynamic inference.bioRxiv : the preprint server for biology · 2025Article
- Optimal vaccination model of airborne infection under variable humidity and demographic heterogeneity for hybrid fractional operator technique.Scientific reports · 2025Article
- Neonatal Microcephaly and Central Nervous System Abnormalities During the Zika Outbreak in Rio de Janeiro.Viruses · 2025Article
- Re-emergence of Oropouche virus as a novel global threat.Current research in microbial sciences · 2025Review
- Tracking down the origin and subsequent spread of SARS-CoV-2 lineage B.1.619.Virus evolution · 2025Article
- Toward optimal disease surveillance with graph-based active learning.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomic surveillance reveals a dengue 2 virus epidemic lineage with a marked decrease in sensitivity to Mosnodenvir.Nature communications · 2024Article
- From GeoSentinel data to epidemiological insights: a multidisciplinary effort towards artificial intelligence-supported detection of infectious disease outbreaks.Journal of travel medicine · 2024Article
- Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.Nature communications · 2024Article
- Long-term co-circulation of multiple arboviruses in southeast Australia revealed by xeno-monitoring and viral whole-genome sequencing.Virus evolution · 2024Article
- Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.medRxiv : the preprint server for health sciences · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
39 authors.
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: nathan.grubaugh@yale.edu.
Sharada SarafDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Karthik GangavarapuDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Alexander WattsLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.
Amanda L TanDepartment of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
Rachel J OidtmanDepartment of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
Jason T LadnerCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
Glenn OliveiraDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nathaniel L MattesonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Moritz U G KraemerDepartment of Zoology, University of Oxford, Oxford OX1 3PS, UK; Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Chantal B F VogelsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Aaron HentoffDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Deepit BhatiaLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.
Danielle StanekBureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
Blake ScottBureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
Vanessa LandisBureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
Ian StrykerBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
Marshall R ConeBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
Edgar W KoppBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
Andrew C CannonsBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
Lea Heberlein-LarsonBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
Stephen WhiteBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA.
Leah D GillisBureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA.
Michael J RicciardiDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Jaclyn KwalDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Paola K LichtenbergerDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Diogo M MagnaniDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
David I WatkinsDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Gustavo PalaciosCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Davidson H HamerDepartment of Global Health, Boston University School of Public Health, Boston, MA 02118, USA; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA 02118, USA.
GeoSentinel Surveillance Network
Lauren M GardnerSchool of Civil and Environmental Engineering, UNSW Sydney, Sydney, NSW 2052, Australia; Department of Civil Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
T Alex PerkinsDepartment of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
Guy BaeleDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.
Kamran KhanLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada; Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON M5B 1T8, Canada.
Andrea MorrisonBureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
Sharon IsernDepartment of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
Scott F MichaelDepartment of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA. Electronic address: smichael@fgcu.edu.
Kristian G AndersenDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Research Translational Institute, La Jolla, CA 92037, USA. Electronic address: andersen@scripps.edu.
Funding
Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Kristian Graugaard Andersen · 2018 to 2026
$32.0MScripps Translational Science InstituteUL1TR002550 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2018 to 2022
$28.9MRESEARCH TRAINING IN PEDIATRIC EMERGENCY MEDICINET32HD040128 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI Kenneth D. Mandl · 2001 to 2026
$5.0MDesign of a human monoclonal antibody-informed dengue vaccineR01AI099210 · NIAID · FLORIDA GULF COAST UNIVERSITY · PI ISERN, SHARON · 2013 to 2016
$1.7MAnalysis of Zika virus emergence and functional evolution in the AmericasR21AI137690 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD · 2018 to 2019
$547kNCATS NIH HHS UL1 TR002550NCEZID CDC HHS U50 CK000189NIAID NIH HHS HHSN272201400048CNIAID NIH HHS R01 AI099210NIAID NIH HHS R21 AI137690NIAID NIH HHS U19 AI135995NICHD NIH HHS T32 HD040128
Abstract
The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identify transmission not captured by reporting. We uncovered an unreported outbreak in Cuba during 2017, a year after peak transmission in neighboring islands. By sequencing Zika virus, we show that the establishment of the virus was delayed by a year and that the ensuing outbreak was sparked by long-lived lineages of Zika virus from other Caribbean islands. Our data suggest that, although mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, such measures need to be maintained to be effective. Our study highlights how Zika virus may still be "silently" spreading and provides a framework for understanding outbreak dynamics. VIDEO ABSTRACT.
Indexed as
EpidemicsAedesAnimalsCubaGenomicsHumansIncidenceMosquito ControlPhylogenyRNA, ViralSequence Analysis, RNATravelWest IndiesZika VirusZika Virus InfectionRNA, Viralclinical sequencinggenomic epidemiologyinfectious disease genomicsphylogeneticstravel surveillancevirus sequencingZika epidemicZika virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.