ArticleCell2019
When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07155993 (FastForward), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FastForward: A Prospective Analysis of Long-term Fasting and Subsequent Food Reintroduction in Humans
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- An Overview of the Effects of Exercise on Viral Infection in Obesity: Recent Advances and Potential Mechanisms.Applied biochemistry and biotechnology · 2026Review
- Dietary influence on lung injury and immune modulation in cadmium-exposed mice.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Metabolic and hormonal effects of an 8 days water only fasting combined with exercise in middle aged men.Scientific reports · 2025Article
- Intermittent fasting in osteoarthritis: from mechanistic insights to therapeutic potential.Frontiers in nutrition · 2025Review
- Dietary restriction in senolysis and prevention and treatment of disease.Critical reviews in food science and nutrition · 2024Review
- Article
- Lymphocytes are less sensitive to autophagy than monocytes during fasting and exercise conditions.Apoptosis : an international journal on programmed cell death · 2022Article
- Calorie restriction has no effect on bone marrow tumour burden in a Vk*MYC transplant model of multiple myeloma.Scientific reports · 2022Article
- The Intersection of Cellular and Systemic Metabolism: Metabolic Syndrome in Systemic Lupus Erythematosus.Endocrinology · 2022Review
- Intermittent Fasting: Potential Utility in the Treatment of Chronic Pain across the Clinical Spectrum.Nutrients · 2022Review
- Autophagy takes it all - autophagy inducers target immune aging.Disease models & mechanisms · 2022Article
- Nutritional Regulation of Mammary Tumor Microenvironment.Frontiers in cell and developmental biology · 2022Review
- Hallmarks of T cell aging.Nature immunology · 2021Review
- Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4Nutrients · 2021Article
- Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.Aging and disease · 2020Article
- Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.Molecular metabolism · 2020Article
- Letter to the Editor: The first Ramadan during COVID-19 pandemic: 1.8 billion Muslims should fast or not?Metabolism: clinical and experimental · 2020Article
- Potential Role of Cellular Senescence in Asthma.Frontiers in cell and developmental biology · 2020Review
- Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic Rewiring.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cycles of fasting reduce autoimmunity and activate lymphocyte-dependent killing of cancer cells, but the mechanisms remain poorly understood. Three studies in this issue of Cell begin to reveal the drastic and complex effects of fasting and severe calorie restriction on the levels and localization of different immune cells and the mechanisms responsible for them.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.