ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Modeling arterial pulse waves in healthy aging: a database for in silico evaluation of hemodynamics and pulse wave indexes.
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- A Multi-Site Measurement System with Photoplethysmographic and Microwave Sensors for Synchronous and Continuous Cardiovascular Signal Acquisition.Sensors (Basel, Switzerland) · 2026Article
- Cardiac timing modulates the contribution of compliance to effective arterial elastance.Physiological reports · 2026Article
- A Virtual Trial to Identify Cardiovascular Biomarkers for Differentiating Diabetic and Hypertensive Kidney Disease.Annals of biomedical engineering · 2026Article
- Synthetic, Population-Based Virtual Patient Database Using a Digital Twin of the Cardiovascular System.Cardiovascular engineering and technology · 2026Article
- First-phase ejection fraction and ventricular-arterial coupling across the lifespan: An in silico analysis.Physiological reports · 2026Article
- Blood Pressure Estimation Through Pulse Wave Analysis Using Features Extracted from Carotid Diameter Distension Waveforms.Biosensors · 2026Article
- [A multi-source information fusion-based method for the local pulse wave velocity estimation in carotid artery].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.Device · 2026Article
- Noninvasive Pulse Measurements for Cardiovascular Health Monitoring and Diagnoses.Advances in experimental medicine and biology · 2026Review
- Synthetic-data-driven LSTM framework for tracing cardiac pulsation in optical signals.Biomedical optics express · 2025Article
- Deep Learning-Enabled Diagnosis of Abdominal Aortic Aneurysm Using Pulse Volume Recording Waveforms: An In Silico Study.Sensors (Basel, Switzerland) · 2025Article
- Predicting in-hospital indicators from wearable-derived signals for cardiovascular and respiratory disease monitoring: An in silico study.PLOS digital health · 2025Article
- A Computationally Efficient and Causal Frequency Domain Formalism for Hemodynamics Allowing for Nonlinearities and Generalized Coupling Conditions.International journal for numerical methods in biomedical engineering · 2025Article
- Electroosmotic hydraulic-based haptic reproduction of human pulse with high accuracy for remote diagnosis.Microsystems & nanoengineering · 2025Article
- An Analytical Model of Motion Artifacts in a Measured Arterial Pulse Signal-Part I: Accelerometers and PPG Sensors.Sensors (Basel, Switzerland) · 2025Article
- An Analytical Model of Motion Artifacts in a Measured Arterial Pulse Signal-Part II: Tactile Sensors.Sensors (Basel, Switzerland) · 2025Article
- Motion Artifacts (MA) At-Rest in Measured Arterial Pulse Signals: Time-Varying Amplitude in Each Harmonic and Non-Flat Harmonic-MA-Coupled Baseline.Biosensors · 2025Article
- Importance of Considering Temporal Variations in Pulse Wave Velocity for Accurate Blood Pressure Prediction.Annals of biomedical engineering · 2025Article
- Flow-Based Coronary Artery Bypass Graft Patency Metrics: Uncertainty Quantification Simulations to Guide Development.Cardiovascular engineering and technology · 2025Article
- Influence of Age and Central Hypertension on the Form Factor Needed to Estimate Mean Aortic Pressure, and Its Implications for Pulse Pressure Amplification: A Secondary Data Analysis.Journal of the American Heart Association · 2025Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It is widely measured by both consumer and clinical devices. However, the physical determinants of the PW are not yet fully understood, and the development of PW analysis algorithms is limited by a lack of PW data sets containing reference CV measurements. Our aim was to create a database of PWs simulated by a computer to span a range of CV conditions, representative of a sample of healthy adults. The typical CV properties of 25-75 yr olds were identified through a literature review. These were used as inputs to a computational model to simulate PWs for subjects of each age decade. Pressure, flow velocity, luminal area, and photoplethysmographic PWs were simulated at common measurement sites, and PW indexes were extracted. The database, containing PWs from 4,374 virtual subjects, was verified by comparing the simulated PWs and derived indexes with corresponding in vivo data. Good agreement was observed, with well-reproduced age-related changes in hemodynamic parameters and PW morphology. The utility of the database was demonstrated through case studies providing novel hemodynamic insights, in silico assessment of PW algorithms, and pilot data to inform the design of clinical PW algorithm assessments. In conclusion, the publicly available PW database is a valuable resource for understanding CV determinants of PWs and for the development and preclinical assessment of PW analysis algorithms. It is particularly useful because the exact CV properties that generated each PW are known.
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