ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019
Estradiol and Follicle-Stimulating Hormone as Predictors of Onset of Menopause Transition-Related Bone Loss in Pre- and Perimenopausal Women.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effect of Tai Chi exercise on bone health and fall prevention in postmenopausal women: a meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
- Repurposing reproductive hormones as a cost-effective triage tool for osteoporosis in resource-limited settings: A prospective study.Medicine · 2026Article
- Review
- Sex and age specific bone mineral density trends in Sri Lankan adults support the need for normative reference data.Frontiers in endocrinology · 2026Article
- Measuring associations between hormonal entropy, the prevalence of vasomotor symptoms, and menstrual dynamics.American journal of physiology. Endocrinology and metabolism · 2025Article
- Patterns of Bone Mineral Density Loss at Multiple Skeletal Sites Following Recent Menopause in Users and Non-Users of Menopausal Hormone Therapy.Calcified tissue international · 2025Article
- Follicle-stimulating hormone: More than a marker for menopause: FSH as a frontier for women's mental health.Psychiatry research · 2025Review
- The association between sex hormones and bone mineral density in US females.Scientific reports · 2025Article
- Study on gut microbiota and metabolomics in postmenopausal women.BMC women's health · 2024Article
- Correlation of Sarcopenic Obesity on Various Cardiometabolic Risk Factors and Fracture Risk in Mid-Aged Korean Women.Journal of menopausal medicine · 2023Article
- [Status Quo and Prospects of Research on Precision Nursing of Life-Cycle Health and Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Association of follicle-stimulating hormone with bone turnover markers and bone mineral density in Chinese women across the menopausal transition.Journal of clinical laboratory analysis · 2023Article
- Follicle-stimulating hormone is associated with low bone mass in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice.Nature communications · 2023Article
- Longitudinal associations of insulin resistance with change in bone mineral density in midlife women.JCI insight · 2022Article
- Roles of Follicle-Stimulating Hormone on Bone Metabolism in Late Postmenopausal Women.Journal of bone metabolism · 2022Article
- Anti-Mullerian Hormone as Predictor of Future and Ongoing Bone Loss During the Menopause Transition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- The prevalence of vertebral fractures among Indian perimenopausal women and its association with ovarian biomarkers.Journal of bone and mineral metabolism · 2022Article
- Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The menopause transition (MT) may be an opportunity for early intervention to prevent rapid bone loss. To intervene early, we need to be able to prospectively identify pre- and perimenopausal women who are beginning to lose bone. This study examined whether estradiol (E2), or follicle-stimulating hormone (FSH), measured in pre- and perimenopausal women, can predict significant bone loss by the next year. Bone loss was considered significant if bone mineral density (BMD) decline at the lumbar spine (LS) or femoral neck (FN) from a pre- or early perimenopausal baseline to 1 year after the E2 or FSH measurement was greater than the least detectable change. We used data from 1559 participants in the Study of Women's Health Across the Nation and tested E2 and FSH as separate predictors using repeated measures modified Poisson regression. Adjusted for MT stage, age, race/ethnicity, and body mass index, women with lower E2 (and higher FSH) were more likely to lose BMD: At the LS, each halving of E2 and each doubling of FSH were associated with 10% and 39% greater risk of significant bone loss, respectively (p < 0.0001 for each). At the FN, each halving of E2 and each doubling of FSH were associated with 12% (p = 0.01) and 27% (p < 0.001) greater risk of significant bone loss. FSH was more informative than E2 (assessed by the area under the receiver-operator curve) at identifying women who were more versus less likely to begin losing bone, especially at the LS. Prediction was better when hormones were measured in pre- or early perimenopause than in late perimenopause. Tracking within-individual change in either hormone did not predict onset of bone loss better than a single measure. We conclude that measuring FSH in the MT can help prospectively identify women with imminent or ongoing bone loss at the LS. © 2019 American Society for Bone and Mineral Research.
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