Trial reportPloS one2019
Lollipop containing Glycyrrhiza uralensis extract reduces Streptococcus mutans colonization and maintains oral microbial diversity in Chinese preschool children.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Comparative Evaluation of Antimicrobial Activity of Licorice, Green Tea, Their Combined Extracts, and Sodium Fluoride Mouthwashes againstInternational journal of clinical pediatric dentistry · 2026Article
- Phytotherapy in Pediatric Dentistry: A Narrative Review of Clinical Applications and Evidence.Children (Basel, Switzerland) · 2025Review
- Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.Dentistry journal · 2025Review
- Formulation and Evaluation of a Licorice-Resveratrol Lollipop for TargetingInfection and drug resistance · 2025Article
- The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects.Current medicinal chemistry · 2025Review
- Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention.Current issues in molecular biology · 2024Review
- Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial.Frontiers in pharmacology · 2024Article
- Formulation and antibacterial properties of lollipops containing of chitosan- zinc oxide nano particles on planktonic and biofilm forms of Streptococcus mutans and Lactobacillus acidophilus.BMC oral health · 2023Article
- Effect of Liquorice Candies on Remineralization of Initial Enamel Carious Lesion.International journal of clinical pediatric dentistry · 2023Article
- The potency of herbal extracts and its green synthesized nanoparticle formulation as antibacterial agents againstBiotechnology reports (Amsterdam, Netherlands) · 2023Article
- Article
- The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions.Phytomedicine plus : international journal of phytotherapy and phytopharmacology · 2021Review
- The complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2021Article
- DexA70, the Truncated Form of a Self-Produced Dextranase, Effectively DisruptsFrontiers in microbiology · 2021Article
- Antimicrobial Effects against Oral Pathogens and Cytotoxicity ofPlants (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
The anticariogenic activity of the extract of Glycyrrhiza uralensis (licorice) has been well documented. We recently developed an herbal lollipop containing licorice extracts with Glycyrrhizol A, the compound displaying strong antimicrobial activity against Streptococcus mutans. Preliminary testing showed that the herbal lollipop reduced salivary S. mutans counts in vivo. In this study, we aimed to further test the efficacy of this herbal lollipop for reducing salivary S. mutans levels, and investigate its impact on salivary microbiome. Using a well-established in vitro oral microbiome model, we showed that licorice extract displays targeted killing against S. mutans without affecting the biodiversity of the community. In vivo study corroborated in vitro findings, showing for high caries-risk children aged 3-6 with salivary S. mutans levels >5x105 cells/ml, daily use of 2 licorice-containing lollipops for 3 weeks significantly reduced salivary S. mutans levels compared to the control group. Salivary microbiome analysis showed either no change or even increase in phylogenetic diversity of the oral community following herbal lollipop usage. Although further study with longer term observation is needed, these results suggest that use of licorice extract-containing lollipops can be as a simple and effective way to reduce the risk of dental caries in children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.