ArticleeLife2019
Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Article
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- Dissecting the spatiotemporal diversity of adult neural stem cells.Molecular systems biology · 2024Article
- Progressively Decreased HCN1 Channels Results in Cone Morphological Defects in Diabetic Retinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain.eLife · 2021Article
- Diverse biological and engineering strategies towards organ regeneration.Cell regeneration (London, England) · 2021Article
- Differential Regenerative Capacity of the Optic Tectum of Adult Medaka and Zebrafish.Frontiers in cell and developmental biology · 2021Article
- Transcriptome Analyses Reveal IL6/Stat3 Signaling Involvement in Radial Glia Proliferation After Stab Wound Injury in the Adult Zebrafish Optic Tectum.Frontiers in cell and developmental biology · 2021Article
- Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain.Development (Cambridge, England) · 2020Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Gliosis defined as reactive changes of resident glia is the primary response of the central nervous system (CNS) to trauma. The proliferation and fate controls of injury-reactivated glia are essential but remain largely unexplored. In zebrafish optic tectum, we found that stab injury drove a subset of radial glia (RG) into the cell cycle, and surprisingly, proliferative RG responding to sequential injuries of the same site were distinct but overlapping, which was in agreement with stochastic cell-cycle entry. Single-cell RNA sequencing analysis and functional assays further revealed the involvement of Notch/Delta lateral inhibition in this stochastic cell-cycle entry. Furthermore, the long-term clonal analysis showed that proliferative RG were largely gliogenic. Notch inhibition of reactive RG, not dormant and proliferative RG, resulted in an increased production of neurons, which were short-lived. Our findings gain new insights into the proliferation and fate controls of injury-reactivated CNS glia in zebrafish.
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