Evidence map›Paper›PMID 31442074›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6.

Federica Bianchi, Daniele Veggi, Laura Santini, Francesca Buricchi, Erika Bartolini, Paola Lo Surdo, Manuele Martinelli, Oretta Finco, Vega Masignani, Matthew J Bottomley and 2 more

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Federica BianchiGlaxoSmithKline, Siena, Italy.
Daniele VeggiGlaxoSmithKline, Siena, Italy.
Laura SantiniGlaxoSmithKline, Siena, Italy.
Francesca BuricchiGlaxoSmithKline, Siena, Italy.
Erika BartoliniGlaxoSmithKline, Siena, Italy.
Paola Lo SurdoGlaxoSmithKline, Rockville, Maryland, USA.
Manuele MartinelliGlaxoSmithKline, Siena, Italy.
Oretta FincoGlaxoSmithKline, Siena, Italy.
Vega MasignaniGlaxoSmithKline, Siena, Italy.
Matthew J BottomleyGlaxoSmithKline, Rockville, Maryland, USA.
Domenico MaioneGlaxoSmithKline, Siena, Italy.
Roberta CozziGlaxoSmithKline, Siena, Italy.
GlaxoSmithKline (India) · INGlaxoSmithKline (Italy) · ITGlaxoSmithKline (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 4 component meningococcus B vaccine (4CMenB) vaccine is the first vaccine containing recombinant proteins licensed for the prevention of invasive meningococcal disease caused by meningococcal serogroup B strains. 4CMenB contains 3 main recombinant proteins, including the

Indexed as

AnimalsAntibodies, MonoclonalAntigens, BacterialBacterial ProteinsComplement Factor HCrystallography, X-RayEpitopesGenetic VariationHumansMeningococcal InfectionsMeningococcal VaccinesModels, MolecularNeisseria meningitidisProtein BindingProtein Conformation4CMenB vaccineAntibodies, MonoclonalAntigens, BacterialBacterial ProteinsComplement Factor HEpitopesfactor H-binding protein, Neisseria meningitidisMeningococcal VaccinesfHbphuman antibodiesNeisseria meningitidisvaccine

Identifiers

PMID31442074
PMCPMC6902690
OpenAlexW2969229784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.