Evidence map›Paper›PMID 31442005›Full record

ArticleChemMedChem2019

Side Chain Orientation of Tryptophan Analogues Determines Agonism and Inverse Agonism in Short Ghrelin Peptides.

Lennart Nicke, Ronny Müller, Armin Geyer, Sylvia Els-Heindl

Open access · hybridAbstract read
In one paragraph

Article in ChemMedChem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Tryptophan Analogues with Fixed Side-Chain Orientation: Expanding the Scope.Chembiochem : a European journal of chemical biology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lennart NickeFaculty of Chemistry, Philipps-University Marburg, Hans-Meerwein-Strasse 4, 35032, Marburg, Germany.
Ronny MüllerFaculty of Life Sciences, Institute of Biochemistry, Leipzig University, Brüderstrasse 34, 04103, Leipzig, Germany.
Armin GeyerFaculty of Chemistry, Philipps-University Marburg, Hans-Meerwein-Strasse 4, 35032, Marburg, Germany.ORCID 0000-0001-8096-2266
Sylvia Els-HeindlFaculty of Life Sciences, Institute of Biochemistry, Leipzig University, Brüderstrasse 34, 04103, Leipzig, Germany.ORCID 0000-0002-1442-0335
Leipzig University · DEPhilipps University of Marburg · DE

Funding

Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung HIMAG-111
6 · The paper itself

Abstract

We describe two synthetic amino acids with inverted side chain stereochemistry, which induce opposite biological activity. Phe

Indexed as

Dose-Response Relationship, DrugGhrelinMolecular StructureReceptors, GhrelinSolid-Phase Synthesis TechniquesStructure-Activity RelationshipTryptophanGhrelinReceptors, GhrelinTryptophandiaryl amino acidsghrelin receptorpeptidesstructure-activity relationships

Identifiers

PMID31442005
PMCPMC6899459
OpenAlexW2969433066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.