Observational studyMedicine2019
Clinical characteristics and chest computed tomography findings of smear-positive and smear-negative pulmonary tuberculosis in hospitalized adult patients.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Survival Analysis of Risk Factors for Death in Patients With TB Based on Clinical and Imaging Characteristics.Canadian respiratory journal · 2026Article
- Analysis of factors influencing high infectivity in patients with tuberculosis using clinical and imaging methods.BMC infectious diseases · 2025Article
- Smear-Negative Pulmonary Tuberculosis with Cavitary Disease in a Young Immigrant Patient: A Diagnostic Challenge.Cureus · 2025Article
- Microbiological aspects and clinical impact of lower lung field tuberculosis: An observational cohort study in Peru.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Observational
- High prevalence and risk factors of positive sputum smear in newly diagnosed pulmonary tuberculosis patients in Vietnam.Le infezioni in medicina · 2025Article
- Construction and Validation of a Nomogram to Identify the Risk of Cavitation in Pulmonary Tuberculosis.Infection and drug resistance · 2024Article
- Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study.Pulmonary medicine · 2024Article
- Review
- Active pulmonary tuberculosis: something old, something new, something borrowed, something blue.Insights into imaging · 2022Review
- Microarray-based selection of a serum biomarker panel that can discriminate between latent and active pulmonary TB.Scientific reports · 2021Article
- Comparison of the diagnostic efficacy of the CapitalBio Mycobacterium real-time polymerase chain reaction detection test and Xpert MTB/RIF in smear-negative pulmonary tuberculosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Article
- Article
- Pulmonary Cryptococcosis in a Nurse Initially Suspected of Having Pulmonary Tuberculosis.The American journal of case reports · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary tuberculosis (PTB) continues to be one of the significant public health threats with significant morbidity and mortality. The present study was aimed to assess the clinical characteristics and chest computed tomography (CT) findings of smear-positive and smear-negative PTB in hospitalized adult patients.Hospitalized adult patients diagnosed with PTB by positive Mycobacterium tuberculosis growth on acid-fast bacilli culture from bronchial aspiration or sputum from 2015 to 2017 were reviewed. Only the patients who had chest CT within 14 days of the diagnosis of PTB were included. Medical records and CT images were analyzed.A total of 189 patients was enrolled. The median age was 62 years, and there were 118 males (62.4%). More than half of the patients had underlying chronic medical conditions (55.5%). The most common CT finding was nodular lesions (96.8%). The patients were categorized in 2 groups of smear-positive (n = 94, 49.7%) and smear-negative (n = 95, 50.3%). Between 2 groups, there was no difference in underlying medical conditions. However, there were more lesions of cavity, consolidation, bronchiectasis, upper lobe involvement, multiple lobe involvement, and lymphadenopathy in the smear-positive group. A predictive model for smear-positive tuberculosis was created based on the comparison analysis that had an area of 0.724 under the receiver operating characteristic curve. In a multivariate logistic regression analysis, CT findings of consolidation (odds ratio [OR] 2.521, 95% confidence interval [CI] 1.175-5.408, P = .02), lymphadenopathy (OR 1.947, 95% CI 1.025-3.696, P = .04), and multi-lobe involvement (OR 2.795, 95% CI 1.084-7.205, P = .03) were associated with smear-positive PTB.PTB patients who have chest CT findings of cavity, consolidation, bronchiectasis, upper lobe involvement, multiple lobe involvement, and lymphadenopathy may be at higher risk for smear-positive TB. A predictive model may be helpful for further assessment.
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