ArticleAnalytical chemistry2019
Quantitative Fragmentation Model for Bottom-Up Shotgun Lipidomics.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- New Analytical Technologies to Resolve, Interpret, and Understand Lipid Complexity.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- Quantitative Lipidomics of Biological Samples Using Supercritical Fluid Chromatography Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Accurate Sphingolipid Quantification Reducing Fragmentation Bias by Nonlinear Models.Analytical chemistry · 2023Article
- Quantitative determination of sn-positional phospholipid isomers in MSAnalytical and bioanalytical chemistry · 2022Article
- Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes.Journal of lipid research · 2022Article
- Article
- Achieving Absolute Molar Lipid Concentrations: A Phospholipidomics Cross-Validation Study.Analytical chemistry · 2022Article
- Tricky Isomers-The Evolution of Analytical Strategies to Characterize Plasmalogens and Plasmanyl Ether Lipids.Frontiers in cell and developmental biology · 2022Review
- Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids.Frontiers in immunology · 2022Article
- Recurrent Topics in Mass Spectrometry-Based Metabolomics and Lipidomics-Standardization, Coverage, and Throughput.Analytical chemistry · 2021Review
- Recommendations for good practice in MS-based lipidomics.Journal of lipid research · 2021Review
- LipidCreator workbench to probe the lipidomic landscape.Nature communications · 2020Article
- Software tools, databases and resources in metabolomics: updates from 2018 to 2019.Metabolomics : Official journal of the Metabolomic Society · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative bottom-up shotgun lipidomics relies on molecular species-specific "signature" fragments consistently detectable in tandem mass spectra of analytes and standards. Molecular species of glycerophospholipids are typically quantified using carboxylate fragments of their fatty acid moieties produced by higher-energy collisional dissociation of their molecular anions. However, employing standards whose fatty acids moieties are similar, yet not identical, to the target lipids could severely compromise their quantification. We developed a generic and portable fragmentation model implemented in the open-source LipidXte software that harmonizes the abundances of carboxylate anion fragments originating from fatty acid moieties having different sn-1/2 positions at the glycerol backbone, length of the hydrocarbon chain, and number and location of double bonds. The postacquisition adjustment enables unbiased absolute (molar) quantification of glycerophospholipid species independent of instrument settings, collision energy, and employed internal standards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.