Evidence map›Paper›PMID 31441426›Full record

Observational studyEmerging infectious diseases2019

Clonality of Fluconazole-Nonsusceptible Candida tropicalis in Bloodstream Infections, Taiwan, 2011-2017.

Pao-Yu Chen, Yu-Chung Chuang, Un-In Wu, Hsin-Yun Sun, Jann-Tay Wang, Wang-Huei Sheng, Hsiu-Jung Lo, Hurng-Yi Wang, Yee-Chun Chen, Shan-Chwen Chang

Open access · diamondAbstract readObservational Study
In one paragraph

Observational study in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Epidemiology of Invasive Candidiasis.Clinical epidemiology · 2024
    Review
  6. Fluconazole and echinocandin resistance ofEpidemiology and infection · 2023
    Observational
  7. Article
  8. A clinical analysis ofFrontiers in microbiology · 2023
    Article
  9. Article
  10. Raman Spectroscopy of OralInternational journal of molecular sciences · 2022
    Article
  11. Review
  12. The emerging threat antifungal-resistantFrontiers in fungal biology · 2022
    Review
  13. A SERS Platform for Rapid Detection of Drug Resistance of Non-International journal of nanomedicine · 2022
    Article
  14. Review
  15. Mechanisms of Azole Resistance and Trailing inJournal of fungi (Basel, Switzerland) · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Pao-Yu Chen
Yu-Chung Chuang
Un-In Wu
Hsin-Yun Sun
Jann-Tay Wang
Wang-Huei Sheng
Hsiu-Jung Lo
Hurng-Yi Wang
Yee-Chun Chen
Shan-Chwen Chang
National Taiwan University · TWNational Taiwan University Hospital · TWNational Health Research Institutes · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida tropicalis is the leading cause of non-C. albicans candidemia in tropical Asia and Latin America. We evaluated isolates from 344 patients with an initial episode of C. tropicalis candidemia. We found that 58 (16.9%) patients were infected by fluconazole-nonsusceptible (FNS) C. tropicalis with cross resistance to itraconazole, voriconazole, and posaconazole; 55.2% (32/58) of patients were azole-naive. Multilocus sequence typing analysis revealed FNS isolates were genetically closely related, but we did not see time- or place-clustering. Among the diploid sequence types (DSTs), we noted DST225, which has been reported from fruit in Taiwan and hospitals in Beijing, China, as well as DST376 and DST505-7, which also were reported from hospitals in Shanghai, China. Our findings suggest cross-boundary expansion of FNS C. tropicalis and highlight the importance of active surveillance of clinical isolates to detect dissemination of this pathogen and explore potential sources in the community.

Indexed as

AgedAntifungal AgentsCandida tropicalisCandidiasis, InvasiveDrug Resistance, FungalFemaleFluconazoleHumansMaleMicrobial Sensitivity TestsMiddle AgedProspective StudiesTaiwanAntifungal AgentsFluconazoleazolescandidemiadrug resistancefungimultilocus sequence typingphylogenyTaiwan

Identifiers

PMID31441426
PMCPMC6711239
OpenAlexW2962988640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.