SynthesisJournal of the American Heart Association2019
Early Experience With Transcatheter Mitral Valve Replacement: A Systematic Review.
Synthesis in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Transcatheter mitral valve implantation with Tendyne System Ten Years since the First In-Human Implant A systematic review.Journal of cardiothoracic surgery · 2023Pooled it
- Paravalvular Leak: A Systemic Review.Current cardiology reviews · 2022Pooled it
- Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Early Experience With Transcatheter Mitral Valve Replacement: A Systematic Review.Journal of the American Heart Association · 2019Pooled it
- Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.JACC. Cardiovascular interventions · 2026Review
- Transcatheter mitral valve replacement or repair for mitral regurgitation: a narrative review.Indian journal of thoracic and cardiovascular surgery · 2025Review
- Prosthetic Heart Valves: More than Half a Century of Innovation-An Overview.Journal of clinical medicine · 2025Review
- Review
- Emerging Transcatheter Therapies for Valvular Heart Disease: Focus on Mitral and Tricuspid Valve Procedures.Life (Basel, Switzerland) · 2024Review
- Surgical Therapy of Infective Prosthesis Endocarditis following TAVI: A Single Center's Experience.Diagnostics (Basel, Switzerland) · 2024Article
- Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support.Journal of biomechanical engineering · 2023Article
- Right atrial structural remodeling predict worse outcomes in transcatheter mitral valve repair.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2023Article
- Transcatheter therapies for secondary mitral regurgitation in advanced heart failure: what are we aiming for?Heart failure reviews · 2022Review
- Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Transcatheter edge-to-edge mitral valve repair in patients with mitral annulus calcification.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Computed tomography angiography/magnetic resonance imaging-based preprocedural planning and guidance in the interventional treatment of structural heart disease.Frontiers in cardiovascular medicine · 2022Article
- Left atrial geometry in an ovine ischemic mitral regurgitation model: implications for transcatheter mitral valve replacement devices with a left atrial anchoring mechanism.Journal of cardiothoracic surgery · 2021Article
- Incorporating the anterior mitral leaflet to the annulus impairs left ventricular function in an ovine model.JTCVS open · 2021Article
- Transapical transcatheter mitral valve implantation in patients with degenerated mitral bioprostheses or failed ring annuloplasty.Annals of cardiothoracic surgery · 2021Article
- Commentary: Chain reaction: Incorporating the anterior mitral leaflet during mitral valve replacement distorts left ventricular mechanics.JTCVS open · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Transcatheter mitral valve replacement (TMVR) has emerged as an alternative therapeutic option for the treatment of severe mitral regurgitation in patients with prohibitive or high surgical risk. The aim of this systematic review is to evaluate the clinical procedural characteristics and outcomes associated with the early TMVR experience. Methods and Results Published studies and international conference presentations reporting data on TMVR systems were identified. Only records including clinical characteristics, procedural results, and 30-day and midterm outcomes were analyzed. A total of 16 publications describing 308 patients were analyzed. Most patients (65.9%) were men, with a mean age of 75 years (range: 69-81 years) and Society for Thoracic Surgery Predicted Risk of Mortality score of 7.7% (range: 6.1-8.6%). The etiology of mitral regurgitation was predominantly secondary or mixed (87.1%), and 81.5% of the patients were in New York Heart Association class III or IV. A transapical approach was used in 81.5% of patients, and overall technical success was high (91.7%). Postprocedural mean transmitral gradient was 3.5 mm Hg (range: 3-5.5 mm Hg), and only 4 cases (1.5%) presented residual moderate to severe mitral regurgitation. Procedural and all-cause 30-day mortality were 4.6% and 13.6%, respectively. Left ventricular outflow obstruction and conversion to open heart surgery were reported in 0.3% and 4% of patients, respectively. All-cause and cardiovascular-related mortality rates were 27.6% and 23.3%, respectively, after a mean follow-up of 10 (range: 3 to 24) months. Conclusions TMVR was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk. TMVR was associated with a high rate of successful valve implantation and excellent hemodynamic results. However, periprocedural complications and all-cause mortality were relatively high.
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