Evidence map›Paper›PMID 31441045›Full record

Trial reportBritish journal of haematology2019

Venetoclax and hypomethylating agents in TP53-mutated acute myeloid leukaemia.

Ibrahim Aldoss, Jianying Zhang, Raju Pillai, Geoffrey Shouse, James F Sanchez, Matthew Mei, Ryotaro Nakamura, Anthony S Stein, Stephen J Forman, Guido Marcucci and 1 more

Abstract readClinical TrialLetter
In one paragraph

Trial report in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. TP53-Mutated Myelodysplasia and Acute Myeloid Leukemia.Mediterranean journal of hematology and infectious diseases · 2023
    Review
  12. Article
  13. How I TreatCancers · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. The Growing Role of the BH3 Mimetic Drug Venetoclax in the Therapy of Acute Myeloid Leukemia.Mediterranean journal of hematology and infectious diseases · 2022
    Review
  18. Venetoclax resistance: mechanistic insights and future strategies.Cancer drug resistance (Alhambra, Calif.) · 2022
    Review
  19. TargetingOncoTargets and therapy · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ibrahim AldossDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.ORCID 0000-0001-9564-4498
Jianying ZhangDepartment of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
Raju PillaiDepartment of Pathology, City of Hope, Duarte, CA, USA.
Geoffrey ShouseDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.
James F SanchezDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.ORCID 0000-0002-2254-6894
Matthew MeiDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.
Ryotaro NakamuraDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.
Anthony S SteinDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.
Stephen J FormanDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.
Guido MarcucciDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.
Vinod PullarkatDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAdultAgedAged, 80 and overBridged Bicyclo Compounds, HeterocyclicFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedRetrospective StudiesSulfonamidesTumor Suppressor Protein p53Bridged Bicyclo Compounds, HeterocyclicSulfonamidesTP53 protein, humanTumor Suppressor Protein p53venetoclaxacute myeloid leukaemiadecitabinehypomethylating agentsTP53venetoclax

Identifiers

PMID31441045
PMCPMC6786919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.