ArticleDigestive diseases and sciences2020
Severe Intestinal Dysbiosis in Rat Models of Short Bowel Syndrome with Ileocecal Resection.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Does Microbiome Matter in Chronic Intestinal Failure Due to Type 1 Short Bowel Syndrome in Adults?Nutrients · 2024Article
- Changes in HLA-B27 Transgenic Rat Fecal Microbiota Following Tofacitinib Treatment and Ileocecal Resection Surgery: Implications for Crohn's Disease Management.International journal of molecular sciences · 2024Article
- Laparoscopic ileocecal-sparing vs traditional right hemicolectomy for cancer of the hepatic flexure or proximal transverse colon: a dual-center propensity score-matched study.Gastroenterology report · 2024Article
- Article
- Dysbiosis and reduced small intestinal function are required to induce intestinal insufficiency in mice.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Altered fecal microbiome and metabolome profiles in rat models of short bowel syndrome.Frontiers in microbiology · 2023Article
- Laparoscopic ileocecal-sparing right hemicolectomy (LISH) for cancers of the hepatic flexure or proximal transverse colon: a video vignette.Techniques in coloproctology · 2021Article
- Therapeutic potential of an intestinotrophic hormone, glucagon-like peptide 2, for treatment of type 2 short bowel syndrome rats with intestinal bacterial and fungal dysbiosis.BMC infectious diseases · 2021Article
- Long-term outcomes of various pediatric short bowel syndrome in China.Pediatric surgery international · 2021Article
- Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency.Digestive diseases and sciences · 2020Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundShort bowel syndrome (SBS) resulting from extensive intestinal resection is thought to significantly affect gut microbiota. Data are limited on the signatures of the intestinal microbiome in SBS with different anatomical types.
aimsThe aim of our investigation was to characterize the composition and function of gut microbiota in SBS with or without ileocecal resection (ICR).
methodsSix-week-old male Sprague-Dawley rats underwent 75% small bowel resection (SBR) with the ileocecal junction intact (SBR group, jejunoileal anastomosis, n = 10) or removed (ICR group, jejunocolic anastomosis, n = 10), or sham surgery (sham group, n = 10). Colonic contents of the rats were collected 28 days after operation, and 16S rRNA gene sequencing was performed on the MiSeq Illumina platform to analyze bacterial composition.
resultsOverall structures of the gut microbiome differed significantly among the three groups. The bacterial α-diversity of the ICR group was remarkably lower than that of the sham group. ICR rats were enriched with Lactobacillus and opportunistic pathogens from Proteobacteria but depleted of commensal genera belonging to the Lachnospiraceae, Ruminococcaceae and Erysipelotrichaceae families. Genera from the Bacteroidales S24-7 group, Porphyromonadaceae, Prevotellaceae, Rikenellaceae and Christensenellaceae were prevalent in SBR rats. Functional pathways of branched-chain and aromatic amino acid biosynthesis, lipopolysaccharide biosynthesis and infectious diseases were abundant in the ICR group, while SBR rats featured pathways of C5 branched dibasic acid metabolism, biotin metabolism and one carbon pool folate.
conclusionsICR causes dramatically more severe intestinal dysbiosis than SBR only in SBS rat models, resulting in altered functional profiles of the gut microbiome.
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