Evidence map›Paper›PMID 31440854›Full record

ArticleEJNMMI research2019

Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis.

Guillaume Rucher, Lucie Cameliere, Jihene Fendri, Antoine Anfray, Ahmed Abbas, Saïd Kamel, Quentin Dupas, Nicolas Delcroix, Ludovic Berger, Alain Manrique and 1 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. The international journal of cardiovascular imaging · 2024
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Medial Arterial Calcification: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021
    Review
  7. Sodium [Cells · 2021
    Article
  8. Review
  9. Atherosclerosis Imaging withDiagnostics (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Guillaume RucherNormandie Univ, UNICAEN, EA 4650, GIP Cyceron, 14000, Caen, France.
Lucie CameliereNormandie Univ, UNICAEN, EA 4650, GIP Cyceron, 14000, Caen, France.
Jihene FendriNormandie Univ, UNICAEN, EA 4650, GIP Cyceron, 14000, Caen, France.
Antoine AnfrayNormandie Univ, UNICAEN, INSERM, UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), 14000, Caen, France.
Ahmed AbbasNormandie Univ, UNICAEN, EPHE, INSERM, U1077, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
Saïd KamelEA7517, MP3CV, CURS, University of Picardie Jules Verne, Amiens, France.
Quentin DupasNormandie Univ, UNICAEN, EA 4650, GIP Cyceron, 14000, Caen, France.
Nicolas DelcroixCNRS, UMS-3048, GIP Cyceron, Campus Jules Horowitz, 14000, Caen, France.
Ludovic BergerNormandie Univ, UNICAEN, EA 4650, GIP Cyceron, 14000, Caen, France.
Alain ManriqueNormandie Univ, UNICAEN, EA 4650, GIP Cyceron, 14000, Caen, France. manrique@cyceron.fr.ORCID http://orcid.org/0000-0002-1578-0922
STOP-AS investigators
Normandie Université · FRInserm · FRCentre National de la Recherche Scientifique · FRCyceron · FRLaboratoire de Biologie Structurale de la Cellule · FR

Funding

Agence Nationale de la Recherche ANR-16-RHUS-0003
6 · The paper itself

Abstract

purposePreclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce. PROCEDURES: A group of uremic ApoE

resultsUr mice showed an active and sustained mineralization process compared to Ctl mice (p = 0.002) using [18F]NaF PET imaging. Calcium plasma level was increased in Ur (2.54 ± 0.09 mM, n = 17) compared to NUr and Ctl mice (2.24 ± 0.01, n = 22, and 2.14 ± 0.02, n = 27, respectively; p < 0.0001). Likewise, vascular calcium content was increased in Ur (0.51 ± 0.06 μg Ca

conclusionsPreclinical molecular imaging allowed in vivo characterization of the early phase of atherosclerosis. [18F]NaF PET showed early and sustained vascular mineralization in uremic ApoE

Indexed as

AtherosclerosisEndothelial activationMagnetic resonance imaging (MRI)MineralizationPositrons emission tomography (PET)

Identifiers

PMID31440854
PMCPMC6706501
OpenAlexW2969683788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.