Evidence map›Paper›PMID 31440771›Full record

ArticleCellular and molecular life sciences : CMLS2020

Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis.

Facundo Ferrero Restelli, Paula Aldana Fontanet, Ana Paula De Vincenti, Tomás Luis Falzone, Fernanda Ledda, Gustavo Paratcha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Facundo Ferrero RestelliDivisión de Neurobiología Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, University of Buenos Aires (UBA), CP1121, Buenos Aires, Argentina.
Paula Aldana FontanetDivisión de Neurobiología Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, University of Buenos Aires (UBA), CP1121, Buenos Aires, Argentina.
Ana Paula De VincentiDivisión de Neurobiología Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, University of Buenos Aires (UBA), CP1121, Buenos Aires, Argentina.
Tomás Luis FalzoneLaboratorio de Transporte Axonal y Enfermedades Neurodegenerativas, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, University of Buenos Aires (UBA), CP1121, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0002-7984-1149
Fernanda LeddaDivisión de Neurobiología Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, University of Buenos Aires (UBA), CP1121, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0002-9769-6926
Gustavo ParatchaDivisión de Neurobiología Molecular y Celular, Instituto de Biología Celular y Neurociencias (IBCN)-CONICET-UBA, Facultad de Medicina, University of Buenos Aires (UBA), CP1121, Buenos Aires, Argentina. gparatcha@fmed.uba.ar.ORCID http://orcid.org/0000-0002-0804-4433
Universidad de Buenos Aires · AR

Funding

Argentine Agency for Promotion of Science and Technology (ANPCyT) PICT 2015-3814Argentine Agency for Promotion of Science and Technology (ANPCyT) PICT 2016-1512Argentine Agency for Promotion of Science and Technology (ANPCyT) PICT 2017-4513
6 · The paper itself

Abstract

The molecular mechanisms that control the biosynthetic trafficking, surface delivery, and degradation of TrkA receptor are essential for proper nerve growth factor (NGF) function, and remain poorly understood. Here, we identify Tetraspanin1 (Tspan1) as a critical regulator of TrkA signaling and neuronal differentiation induced by NGF. Tspan1 is expressed by developing TrkA-positive dorsal root ganglion (DRG) neurons and its downregulation in sensory neurons inhibits NGF-mediated axonal growth. In addition, our data demonstrate that Tspan1 forms a molecular complex with the immature form of TrkA localized in the endoplasmic reticulum (ER). Finally, knockdown of Tspan1 reduces the surface levels of TrkA by promoting its preferential sorting towards the autophagy/lysosomal degradation pathway. Together, these data establish a novel homeostatic role of Tspan1, coordinating the biosynthetic trafficking and degradation of TrkA, regardless the presence of NGF.

Indexed as

NeurogenesisProteostasisSignal TransductionAnimalsFemaleHEK293 CellsHumansMaleNerve Growth FactorPC12 CellsRatsRats, WistarReceptor, trkATetraspaninsNerve Growth FactorNgf protein, ratReceptor, trkATetraspaninsTspan1 protein, ratNeuronal differentiation and receptor proteostasisNeurotrophinsSensory neuronsTetraspanins (Tspans)TrkA

Identifiers

PMID31440771
PMCPMC11104797
OpenAlexW2969759433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.