ArticleKidney international reports2019
Kidney Tubular Damage and Functional Biomarkers in Acute Kidney Injury Following Cardiac Surgery.
Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- The association of early glomerular filtration kinetics and urinary urea excretion with subsequent renal replacement therapy under a delayed strategy in severe acute kidney injury.Critical care (London, England) · 2026Article
- Urinary Calprotectin Predicts Severe Acute Kidney Injury After Non-cardiac Surgery in Surgical Intensive Care Unit: A Prospective Cohort Study.Biomarker insights · 2026Article
- Performance of Cleveland, Mehta, and Simplified Renal Index scores for predicting dialysis-requiring acute kidney injury after aorticRenal failure · 2025Article
- Kidney Tubular Biomarkers in Type 1 Diabetes - Longitudinal Analysis of 2 Cohorts.Kidney international reports · 2025Article
- Rapid-onset postoperative acute kidney injury is associated with mortality in patients with postcardiotomy cardiogenic shock.Frontiers in cardiovascular medicine · 2025Article
- Iron metabolism indexes as predictors of the incidence of cardiac surgery-associated acute kidney surgery.Journal of cardiothoracic surgery · 2024Observational
- Recent Progress in Molecular Probes for Imaging of Acute Kidney Injury.Chemical & biomedical imaging · 2024Review
- Longitudinal Trajectories of Biomarkers of Kidney Tubular Function in Type 1 Diabetes.Kidney international reports · 2024Article
- Prediction of acute kidney injury incidence following acute type A aortic dissection surgery with novel biomarkers: a prospective observational study.BMC medicine · 2023Observational
- Urinary neutrophil gelatinase-associated lipocalin predicted to contrast-associated acute kidney injury after planned percutaneous coronary intervention in elderly patients.Journal of clinical laboratory analysis · 2022Article
- Enhanced Detection of Cardiac Surgery-Associated Acute Kidney Injury by a Composite Biomarker Panel in Patients with Normal Preoperative Kidney Function.Journal of cardiovascular development and disease · 2022Article
- Machine learning to predict post-operative acute kidney injury stage 3 after heart transplantation.BMC cardiovascular disorders · 2022Article
- Selenoprotein P-1 (SEPP1) as an Early Biomarker of Acute Kidney Injury in Patients Undergoing Cardiopulmonary Bypass.Reviews in cardiovascular medicine · 2022Article
- Experimental models of acute kidney injury for translational research.Nature reviews. Nephrology · 2022Review
- Assessment of a modified renal angina index for AKI prediction in critically ill adults.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Meta-analysis of AKI to CKD transition in perioperative patients.Perioperative medicine (London, England) · 2021Article
- Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery.Antioxidants (Basel, Switzerland) · 2021Article
- Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Observational
- Acute Kidney Injury following Cardiopulmonary Bypass: A Challenging Picture.Oxidative medicine and cellular longevity · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCardiac surgery-associated acute kidney injury (AKI) is associated with increased morbidity and mortality. We examined the utility of combining biomarkers of kidney function loss (serum cystatin C) and kidney tubular damage (urine neutrophil gelatinase-associated lipocalin [NGAL] and Kidney Injury Molecule-1 [KIM-1]) for the prediction of post-cardiac surgery AKI.
methodsSingle-center prospective cohort study of 106 adults undergoing coronary artery bypass grafting and/or valve surgery with cardiopulmonary bypass (CPB). Primary outcome was postoperative in-hospital AKI defined by serum creatinine (SCr)-Kidney Disease: Improving Global Outcomes criteria. Biomarkers were measured preoperatively, 6 hours after CPB and on postoperative days (PODs) 1 to 4.
resultsA total of 23 subjects (21.7%) developed AKI. After adjusting for preoperative left ventricular ejection fraction, body mass index >30 kg/m
conclusionsCombining biomarkers of postoperative kidney function loss and postoperative kidney tubular damage significantly improved prediction of in-hospital AKI following cardiac surgery. Future large, multicenter studies are warranted to assess whether panels of biomarkers reflecting distinct pathobiology can be used to guide interventions and improve short- and long-term outcomes in patients undergoing cardiac surgery.
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