Evidence map›Paper›PMID 31440700›Full record

ArticleKidney international reports2019

Micronutrient and Amino Acid Losses During Renal Replacement Therapy for Acute Kidney Injury.

Weng C Oh, Bruno Mafrici, Mark Rigby, Daniel Harvey, Andrew Sharman, Jennifer C Allen, Ravi Mahajan, David S Gardner, Mark A J Devonald

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Observational
  9. Nutrition support for patients with renal dysfunction in the intensive care unit: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  10. Observational
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Intensive Care Unit-Acquired Weakness in Patients With Acute Kidney Injury: A Contemporary Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Review
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Weng C OhRenal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Bruno MafriciRenal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Mark RigbyRenal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Daniel HarveyDepartment of Intensive Care Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Andrew SharmanDepartment of Intensive Care Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Jennifer C AllenRenal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Ravi MahajanSchool of Medicine, University of Nottingham, Nottingham, UK.
David S GardnerSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Mark A J DevonaldRenal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Nottingham University Hospitals NHS Trust · GBUniversity of Nottingham · GB

Funding

Department of Health PB-PG-0613-31042
6 · The paper itself

Abstract

introductionMalnutrition is common in patients with acute kidney injury (AKI), particularly in those requiring renal replacement therapy (RRT). Use of RRT removes metabolic waste products and toxins, but it will inevitably also remove useful molecules such as micronutrients, which might aggravate malnutrition. The RRT modalities vary in mechanism of solute removal; for example, intermittent hemodialysis (IHD) uses diffusion, continuous veno-venous hemofiltration (CVVH) uses convection, and sustained low-efficiency diafiltration (SLEDf) uses a combination of these.

methodsWe assessed micronutrient and amino acid losses in 3 different RRT modalities in patients with AKI (IHD, n = 27; SLEDf, n = 12; CVVH, n = 21) after correction for dialysis dose and plasma concentrations.

resultsTotal losses were affected by modality; generally CVVH >> SLEDf > IHD (e.g., amino acid loss was 18.69 ± 3.04, 8.21 ± 4.07, and 5.13 ± 3.1 g, respectively;

conclusionMicronutrient and amino acid losses are marked during RRT in patients with AKI, with variation between RRT modalities and micronutrients.

Indexed as

acute kidney injuryamino acidsB vitaminsmalnutritionrenal replacement therapytrace elements

Identifiers

PMID31440700
PMCPMC6698297
OpenAlexW2946459725

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.