Evidence map›Paper›PMID 31440615›Full record

ArticleSpine surgery and related research2017

Spinal fusion on adolescent idiopathic scoliosis patients with the level of L4 or lower can increase lumbar disc degeneration with sagittal imbalance 35 years after surgery.

Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Shohei Minami, Sumihisa Orita, Kazuki Fujimoto, Yasuhiro Shiga, Masashi Takaso, Gen Inoue, Masayuki Miyagi and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Spine surgery and related research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Evolution of surgical strategy for superior kyphosis restoration in patients with Lenke 1 & 2 adolescent idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  11. Does intervertebral disc degeneration in adolescent idiopathic scoliosis correlate with patient-reported pain scores? A review of 968 cases.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Review
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  16. Specific sagittal alignment patterns are already present in mild adolescent idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Article
  17. Mid-long-term outcome and degeneration of the remaining unfused lumbar intervertebral disc in adolescent idiopathic scoliosis patients who had posterior spinal fusion surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Article
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  20. Comparison of different strategies on three-dimensional correction of AIS: which plane will suffer?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Tsutomu AkazawaDepartment of Orthopaedic Surgery, St. Marianna University School of Medicine, Japan.
Toshiaki KotaniDepartment of Orthopedic Surgery, Seirei Sakura Citizen Hospital, Japan.
Tsuyoshi SakumaDepartment of Orthopedic Surgery, Seirei Sakura Citizen Hospital, Japan.
Shohei MinamiDepartment of Orthopedic Surgery, Seirei Sakura Citizen Hospital, Japan.
Sumihisa OritaDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Japan.
Kazuki FujimotoDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Japan.
Yasuhiro ShigaDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Japan.
Masashi TakasoDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Japan.
Gen InoueDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Japan.
Masayuki MiyagiDepartment of Orthopaedic Surgery, Kitasato University School of Medicine, Japan.
Yasuchika AokiDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Japan.
Hisateru NikiDepartment of Orthopaedic Surgery, St. Marianna University School of Medicine, Japan.
Yoshiaki ToriiDepartment of Orthopaedic Surgery, St. Marianna University School of Medicine, Japan.
Shigeta MoriokaDepartment of Orthopaedic Surgery, St. Marianna University School of Medicine, Japan.
Seiji OhtoriDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Japan.
Kazuhisa TakahashiDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Japan.
Chiba University · JPSeirei Sakura Citizen Hospital · JPKitasato University · JPSt. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this study was to investigate the long-term incidence of lumbar disc degeneration and Modic changes in the non-fused segments of patients with adolescent idiopathic scoliosis (AIS) who previously underwent spinal fusion.

methodsStudy subjects consisted of 252 patients with AIS who underwent spinal fusion between 1968 and 1988. Of 252 patients, 35 subjects underwent lumbar spine MRI and whole spine X-ray examination. The mean patient age at the time of follow-up was 49.8 years, with an average follow-up period of 35.1 years. We classified the subjects into two groups based on the lowest fused vertebra: H group whose lowest fused vertebra was L3 or higher levels and L group whose lowest fused vertebra was L4 or lower levels.

resultsThe L group had significantly advanced disc degeneration on MRI. There was no significant difference between two groups in Modic changes. The L group showed less lumbar lordosis than the H group (H group: 48.1 degrees; and L group: 32.1 degrees) and greater SVA (H group: 1.2 cm; and L group: 5.5 cm).

conclusionsIn AIS patients, 35 years after spinal fusion surgery on average, we evaluated lumbar disc degeneration and Modic changes of the non-fused segments. In patients with the lowest fusion level at L4 or lower, there were reduced lumbar lordosis, considerable SVA imbalance, and severe disc degeneration compared with those with the lowest fusion level at L3 or higher. The lowest fusion level at L3 or higher is recommended to reduce disc degeneration in midlife.

Indexed as

adolescent idiopathic scoliosislong-term follow-uplumbar disc degenerationModic changespinal fusion

Identifiers

PMID31440615
PMCPMC6698554
OpenAlexW2607939715

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.