Evidence map›Paper›PMID 31440580›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2019

Focused transcranial ultrasound for treatment of neurodegenerative dementia.

Natalie Eleanor Nicodemus, Sergio Becerra, Taylor P Kuhn, Hannah R Packham, John Duncan, Kennedy Mahdavi, Jessica Iovine, Santosh Kesari, Scott Pereles, Mike Whitney and 4 more

Expression of concernOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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  10. Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Natalie Eleanor NicodemusNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
Sergio BecerraNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
Taylor P KuhnDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA.
Hannah R PackhamNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
John DuncanNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
Kennedy MahdaviNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
Jessica IovineNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
Santosh KesariJohn Wayne Cancer Institute, Santa Monica, CA.
Scott PerelesRAD Alliance, Los Angeles, CA.
Mike WhitneyRAD Alliance, Los Angeles, CA.
Michael MamounDepartments of Research and Psychiatry, VA Greater Los Angeles Healthcare System, Los Angeles, Los Angeles, CA.
Daniel FrancLos Angeles Brain Science Project, Santa Monica, CA.
Alexander BystritskySemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA.
Sheldon JordanNeurological Associates - The Interventional Group, USA, Los Angeles, CA.
AIDS Research Alliance · USUniversity of California, Los Angeles · USAPLA Health · USSaint John's Health Center · USSanta Monica College · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPreclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).

methodsA focused transcranial Doppler device with probes (2 MHz, 520 mW/cm

resultsOf all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported. DISCUSSION: The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.

Indexed as

Alzheimer'sASLCognitionDementiaParkinson'sSleepUltrasound

Identifiers

PMID31440580
PMCPMC6700262
OpenAlexW2967354305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.