Evidence map›Paper›PMID 31440477›Full record

ArticleFrontiers in cellular and infection microbiology2019

Influenza Virus Infection Induces ZBP1 Expression and Necroptosis in Mouse Lungs.

Yun Wang, Qin Hao, Jon M Florence, Bock-Gie Jung, Anna K Kurdowska, Buka Samten, Steven Idell, Hua Tang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Induced necroptosis limitsInfection and immunity · 2025
    Article
  3. Review
  4. Cell-Autonomous Immunity: From Cytosolic Sensing to Self-Defense.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yun WangDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Qin HaoDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Jon M FlorenceDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Bock-Gie JungDepartment of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Anna K KurdowskaDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Buka SamtenDepartment of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Steven IdellDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Hua TangDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
The University of Texas Health Science Center at Tyler · US

Funding

Identification of Novel Necroptosis Pathways in Human Lung Epithelial CellsR21AI135569 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI TANG, HUA · 2018 to 2019
$390k
NIAID NIH HHS R21 AI135569
6 · The paper itself

Abstract

Programmed cell death and especially necroptosis, a programmed and regulated form of necrosis, have been recently implicated in the progression and outcomes of influenza in mouse models. Moreover, Z-DNA/RNA binding protein 1 (ZBP1) has been identified as a key signaling molecule for necroptosis induced by Influenza A virus (IAV). Direct evidence of IAV-induced necroptosis has not been shown in infected lungs

Indexed as

Gene ExpressionNecroptosisAlveolar Epithelial CellsAnimalsBiomarkersCytokinesHost-Pathogen InteractionsImmunohistochemistryInflammation MediatorsInfluenza A virusLungMiceOrthomyxoviridae InfectionsPhosphorylationRNA-Binding ProteinsBiomarkersCytokinesInflammation MediatorsRNA-Binding ProteinsZbp1 protein, mouseInfluenza A viruslungnecroptosisprogrammed cell deathZBP1

Identifiers

PMID31440477
PMCPMC6694206
OpenAlexW2963368535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.