Evidence map›Paper›PMID 31440475›Full record

ArticleFrontiers in cellular and infection microbiology2019

Pathogen Evasion of Chemokine Response Through Suppression of CXCL10.

Alejandro L Antonia, Kyle D Gibbs, Esme D Trahair, Kelly J Pittman, Amelia T Martin, Benjamin H Schott, Jeffrey S Smith, Sudarshan Rajagopal, J Will Thompson, Richard Lee Reinhardt and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 citations in OpenAlex.

  1. Characterization of an isogenicInfection and immunity · 2026
    Article
  2. Article
  3. Article
  4. CD4Nature communications · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Inflammatory Patterns Associated withPathogens (Basel, Switzerland) · 2024
    Article
  13. Article
  14. Infection and immunity · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Dissection of the macrophage response towards infection by theFrontiers in cellular and infection microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alejandro L AntoniaDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Kyle D GibbsDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Esme D TrahairDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Kelly J PittmanDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Amelia T MartinDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Benjamin H SchottDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Jeffrey S SmithDepartment of Biochemistry, School of Medicine, Duke University, Durham, NC, United States.
Sudarshan RajagopalDepartment of Biochemistry, School of Medicine, Duke University, Durham, NC, United States.
J Will ThompsonProteomics and Metabolomics Shared Resource, Center for Genomics and Computational Biology, School of Medicine, Duke University, Durham, NC, United States.
Richard Lee ReinhardtDepartment of Biomedical Research, National Jewish Health, Denver, CO, United States.
Dennis C KoDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.
Duke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Serologic Biomarkers of Human Sexually Transmitted Infection and DiseaseU19AI084044 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI TERPLAN, MISHKA · 2009 to 2018
$22.8M
Biasing CXCR3 Signaling to Modulate the Inflammatory ResponseR01GM122798 · NIGMS · DUKE UNIVERSITY · PI RAJAGOPAL, SUDARSHAN · 2017 to 2025
$3.2M
The Role of BATF in Allergic Inflammation and Anti-Helminth ImmunityR01AI119004 · NIAID · NATIONAL JEWISH HEALTH · PI REINHARDT, RICHARD LEE · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI119004NIAID NIH HHS U19 AI084044NIGMS NIH HHS R01 GM122798NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Clearance of intracellular pathogens, such as Importance: Leishmaniasis, an infectious disease that annually affects over one million people, is caused by intracellular parasites that have evolved to evade the host's attempts to eliminate the parasite. Cutaneous leishmaniasis results in disfiguring skin lesions if the host immune system does not appropriately respond to infection. A family of molecules called chemokines coordinate recruitment of the immune cells required to eliminate infection. Here, we demonstrate a novel mechanism that

Indexed as

Immune EvasionCell LineChemokine CXCL10Chlamydia trachomatisHumansImmunologic FactorsImmunosuppression TherapyLeishmania majorMetalloendopeptidasesMonocytesProtein BiosynthesisProteolysisSalmonella entericaT-LymphocytesTranscription, GeneticChemokine CXCL10CXCL10 protein, humanglycoprotein gp63, LeishmaniaImmunologic FactorsMetalloendopeptidasesChlamydiaconvergent evolutionCXCL10CXCR3gp63LeishmanialeishmanolysinSalmonella

Identifiers

PMID31440475
PMCPMC6693555
OpenAlexW2917082624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.