ArticleToxicology reports2019
A new method for quantifying causative and diagnostic markers of methylenecyclopropylglycine poisoning.
Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Derivatisation-free FIA-MS/MS assay for rapid simultaneous screening of atypical myopathy biomarkers and acylcarnitine profiles from dried blood spots.Analytical and bioanalytical chemistry · 2026Article
- New Pathophysiological Insights from Serum Proteome Profiling in Equine Atypical Myopathy.ACS omega · 2024Article
- Tissue Specific Distribution and Activation ofAnimals : an open access journal from MDPI · 2023Article
- Methylenecyclopropylglycine and hypoglycin A intoxication in three Pére David's Deers (Elaphurus davidianus) with atypical myopathy.Veterinary medicine and science · 2021Article
- Severe Inhibition of Long-Chain Acyl-CoA Enoylhydratase (EC 4.2.1.74) in a Newborn Foal Suffering From Atypical Myopathy.Frontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUp to now quantification of hypoglycin A in serum and urine in the range of nmols to μmols per liter plus the measurement of accumulated acyl conjugates have been used for the diagnosis of poisoning by fruits or seeds of
methodMethylenecyclopropylglycine was extracted from serum and urine of a volunteer by a methanolic solution containing labeled methylenecyclopropylglycine as internal standard. UPLC-MS/MS analysis was performed after butylation.
resultsLower limits of detection and quantification were found at 0.5 and 2.5 nmol/L respectively in both urine and serum for each of two isomers, linearity of results (r
conclusionsQuantification of methylenecyclopropylglycine can be successfully integrated into our established analytical procedure used for clinical diagnosis of
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