Evidence map›Paper›PMID 31440440›Full record

ArticleAllergo journal international2018

Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy.

Wenming Zhang, Sayantani B Sindher, Vanitha Sampath, Kari Nadeau

Abstract read
In one paragraph

Article in Allergo journal international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Formulation andSaudi journal of biological sciences · 2022
    Article
  6. Treatment Approaches to Food Allergy.Handbook of experimental pharmacology · 2022
    Review
  7. Exercise induced anaphylaxis in kiwi allergic patient: case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  8. Food Allergy from Infancy Through Adulthood.The journal of allergy and clinical immunology. In practice · 2020
    Review
  9. [Research advances in influencing factors for immune tolerance to food allergens in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenming ZhangSean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, USA.
Sayantani B SindherSean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, USA.
Vanitha SampathSean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, USA.
Kari NadeauSean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, USA.

Funding

Tracking allergen specific T cells in multi-food allergyU19AI104209 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2013 to 2025
$17.3M
NIAID NIH HHS U19 AI104209
6 · The paper itself

Abstract

The prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be more efficacious that SLIT with an acceptable safety profile. However, SLIT is associated with fewer side effects. Studies indicate that a combination of SLIT and OIT may together induce a significant increase in challenge thresholds with fewer adverse events. More head-to-head clinical trials that direct compare OIT and SLIT as well as SLIT and OIT combination studies are warranted.

Indexed as

food allergyoral immunotherapypeanut allergysublingual immunotherapy

Identifiers

PMID31440440
PMCPMC6705598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.