Evidence map›Paper›PMID 31440392›Full record

ReviewAging and disease2019

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways.

Georg Fuellen, Ludger Jansen, Alan A Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal and 3 more

Abstract readReview
In one paragraph

Review in Aging and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Trial
  2. Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026
    Review
  3. A proteomic signature of healthspan.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. A proteomic signature of healthspan.medRxiv : the preprint server for health sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Geroscience in the continuum from healthy longevity to frailty.Zeitschrift fur Gerontologie und Geriatrie · 2024
    Review
  12. [Strengthening prevention and health promotion in and for old age].Zeitschrift fur Gerontologie und Geriatrie · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Georg Fuellen1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany.
Ludger Jansen2Institute of Philosophy, University of Rostock, Germany.
Alan A Cohen3Department of Family Medicine, University of Sherbrooke, Sherbrooke, Canada.
Walter Luyten4KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.
Manfred Gogol5Institute of Gerontology, University Heidelberg, Germany.
Andreas Simm6Department of Cardiac Surgery, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Nadine Saul7Humboldt-University of Berlin, Institute of Biology, Berlin, Germany.
Francesca Cirulli8Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Italy.
Alessandra Berry8Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Italy.
Peter Antal9Budapest University of Technology and Economics, Budapest, Hungary.
Rüdiger Köhling11Rostock University Medical Center, Institute for Physiology, Rostock, Germany.
Brecht Wouters12KU Leuven, Department of Biology, Leuven, Belgium.
Steffen Möller1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite increasing research efforts, there is a lack of consensus on defining aging or health. To understand the underlying processes, and to foster the development of targeted interventions towards increasing one's health, there is an urgent need to find a broadly acceptable and useful definition of health, based on a list of (molecular) features; to operationalize features of health so that it can be measured; to identify predictive biomarkers and (molecular) pathways of health; and to suggest interventions, such as nutrition and exercise, targeted at putative causal pathways and processes. Based on a survey of the literature, we propose to define

Indexed as

agingbiological agebiomarkerhealthterminologywellbeing

Identifiers

PMID31440392
PMCPMC6675520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.