ArticleFrontiers in physiology2019
Early Postnatal Heart Rate Variability in Healthy Newborn Infants.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Heart Rate Variability Analysis to Evaluate Autonomic Nervous System Maturation in Neonates: An Expert Opinion.Frontiers in pediatrics · 2022Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Trial
- Prenatal maternal distress and fetal heart rate: Examining sex-specific sensitivity.Journal of affective disorders · 2026Article
- The developing relationship between circadian rhythm and heart rate variability in premature infants.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Maturational physiology in preterm infants: morbidity impact and 2-year neurodevelopmental outcome.Pediatric research · 2026Article
- Heart Rate Variability in Newborns From Diabetic Mothers: Clinical Application and Significance.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Review
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- Autonomic nervous system maturation in preterm neonates: Correlation with gestational and postmenstrual age (ProMote).PloS one · 2026Article
- Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Establishing normative values for short-term heart rate variability indices in healthy infants in the emergency department.Annals of translational medicine · 2025Article
- Lipopolysaccharide induced systemic inflammation and heart rate variability in a term newborn piglet model.Pediatric research · 2025Article
- Heart rate variability and its modulation by nutrients: a narrative review on implications for cardiovascular aging.Frontiers in neuroscience · 2025Review
- Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prediction of outcome of hypoxic-ischemic encephalopathy in newborns undergoing therapeutic hypothermia using heart rate variability.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Impact of low-level prenatal alcohol exposure and maternal stress on autonomic regulation.Pediatric research · 2024Article
- Exposure to prenatal stressors and infant autonomic nervous system regulation of stress.Stress (Amsterdam, Netherlands) · 2024Article
- Sympathetic nervous system activity and pain-related response indexed by electrodermal activity during the earliest postnatal life in healthy term neonates.Physiological research · 2023Article
- Comparison of oxygen supplementation in very preterm infants: Variations of oxygen saturation features and their application to hypoxemic episode based risk stratification.Frontiers in pediatrics · 2023Article
- Heart Rate Variability in Children and Adolescents with Autism, ADHD and Co-occurring Autism and ADHD, During Passive and Active Experimental Conditions.Journal of autism and developmental disorders · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the increasing interest in fetal and neonatal heart rate variability (HRV) analysis and its potential use as a tool for early disease stratification, no studies have previously described the normal trends of HRV in healthy babies during the first hours of postnatal life.
methodsWe prospectively recruited 150 healthy babies from the postnatal ward and continuously recorded their electrocardiogram during the first 24 h after birth. Babies were included if born in good condition and stayed with their mother. Babies requiring any medication or treatment were excluded. Five-minute segments of the electrocardiogram (non-overlapping time-windows) with more than 90% consecutive good quality beats were included in the calculation of hourly medians and interquartile ranges to describe HRV trends over the first 24 h. We used multilevel mixed effects regression with auto-regressive covariance structure for all repeated measures analysis and
resultsNine out of 16 HRV metrics (including heart rate) changed significantly over the 24 h [Heart rate
conclusionHeart rate variability changes significantly during the first day of life, particularly during the first 6 h. The significant correlations between HRV and clinical risk variables support the hypothesis that HRV is a good indicator of overall wellbeing of a baby and is sensitive to detect birth-related stress and monitor its resolution over time.
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