Evidence map›Paper›PMID 31440163›Full record

ReviewFrontiers in physiology2019

Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action.

Yi Zhu, Jing Qu, Li He, Feng Zhang, Zijing Zhou, Shanzhong Yang, Yong Zhou

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Vascular and Glycemic Modulation byPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Vessel-On-A-Chip Coupled Proteomics Reveal Pressure-Overload-Induced Vascular Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  19. Article
  20. Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yi ZhuDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
Jing QuDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
Li HeDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
Feng ZhangDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
Zijing ZhouDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
Shanzhong YangDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
Yong ZhouDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USCentral South University · CNHuazhong University of Science and Technology · CNSecond Xiangya Hospital of Central South University · CN

Funding

Targeting Matrix Stiffness in Lung Fibrosis Associated with AgingR01HL139584 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, YONG · 2018 to 2024
$2.2M
Optic Nerve Head Mechanobiology in GlaucomaR01EY027924 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOWNS, J CRAWFORD, MURPHY-ULLRICH, JOANNE E · 2018 to 2021
$1.8M
The Role of Biomechanical Signaling in Lung FibrosisR01HL124076 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, YONG · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL124076NHLBI NIH HHS R01 HL139584
6 · The paper itself

Abstract

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall. These cells play a critical role in maintaining vascular homeostasis including vasoconstriction and vasodilatation through active contraction and relaxation. Dysregulation of VSMC function alters the response of blood vessels to mechanical stress, contributing to the pathogenesis of vascular diseases, particularly atherosclerosis and hypertension. The stiffness of VSMCs is a major regulator of vascular function. Previous studies suggest that intracellular Ca

Indexed as

adhesioncalciumelasticityextracellular matrix-integrin-cytoskeletal axisvascular smooth muscle cell

Identifiers

PMID31440163
PMCPMC6693425
OpenAlexW2966144314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.