Evidence map›Paper›PMID 31440156›Full record

ArticleFrontiers in aging neuroscience2019

Insulin Resistance Predicts Postoperative Cognitive Dysfunction in Elderly Gastrointestinal Patients.

Xi He, Ge Long, Chengxuan Quan, Bin Zhang, Jia Chen, Wen Ouyang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04206189 (Effect of Preoperative Oral Carbohydrates on the Insulin Resistance of Elderly Patients), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04206189 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of Preoperative Oral Carbohydrates on the Insulin Resistance of Elderly Patients

TypeinterventionalSponsorYonsei UniversityRan2020 to 2021Enrolled56ConditionsOld AgeArmscarbohydrate group - carbohydrate (400ml)
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  7. Postoperative cognitive dysfunction: a concept analysis.Aging clinical and experimental research · 2024
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  12. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xi HeDepartment of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, China.
Ge LongDepartment of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, China.
Chengxuan QuanDepartment of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, China.
Bin ZhangDepartment of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, China.
Jia ChenDepartment of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, China.
Wen OuyangDepartment of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMembers of the aging population who undergo surgery are at risk of postoperative cognitive dysfunction (POCD). Exploring an effective and reliable early predictor of POCD is essential to the identification of high-risk patients and to making prospective decisions. The purpose of this study was to examine whether preoperative insulin resistance is an independent predictor of POCD.

methodsA total of 124 patients aged 60 years and older and who were scheduled for gastrointestinal surgery were enrolled in a prospective observational clinical study. All participants completed a battery of neuropsychological tests before surgery and 7 days later. POCD was defined as a decline of at least 1.5 SD on two or more of neuropsychological tests. Plasma concentration of the tumor necrosis factor α (TNF-α), C-reactive protein (CRP), and S-100β protein were measured. The status of insulin resistance was assessed by Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). The relationship between HOMA-IR and POCD was assessed by Multivariable logistic regression models and the receiver operating characteristic (ROC) curve.

resultsFifty one patients (41.1%) were diagnosed with POCD at 7 days after surgery. Preoperative HOMA-IR values of the POCD group were significantly higher than the non-POCD group. Furthermore, CRP and TNF-α levels of the POCD group were significantly higher at each postoperative time point (

conclusionPreoperative insulin resistance is an effective predictor for the occurrence of POCD. Targeted prevention and treatment strategies of insulin resistance may be effective interventions of patients at risk for POCD.

Indexed as

elderlyinsulin resistancemetabolic risk factorspostoperative cognitive dysfunctiontumor necrosis factor α

Identifiers

PMID31440156
PMCPMC6694405
OpenAlexW2957682139

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.