ReviewJournal of pain research2019
Mesotherapy in the treatment of musculoskeletal pain in rehabilitation: the state of the art.
Review in Journal of pain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Safety and efficacy of mesotherapy in musculoskeletal disorders: A systematic review of randomized controlled trials with meta-analysis.Journal of rehabilitation medicine · 2021Pooled it
- Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double-Blind Trial.Pain practice : the official journal of World Institute of Pain · 2026Trial
- Blood biomarkers of inflammation and brain-derived neurotrophic factor can not be used to assess the effectiveness of collagen mesotherapy in chronic cervical myofascial pain syndrome. A pilot single-blind randomized study.Rheumatology international · 2026Trial
- Comparison of Mesotherapy and Transcutaneous Electrical Nerve Stimulation (TENS) in the Management of Chronic Non-Specific Low Back Pain: A Randomized Clinical Trial.La Tunisie medicale · 2025Trial
- Efficacy of Mesotherapy for Pain, Function and Quality of Life in Patients with Mild and Moderate Knee Osteoarthritis: A Randomized Controlled Trial.Journal of musculoskeletal & neuronal interactions · 2023Trial
- Evaluation of the Efficacy and Safety of Collagen Mesotherapy in the Course of Chronic Cervicocephalic Syndrome-A Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Efficacy of mesotherapy in patients with acute and subacute neck pain: A randomized controlled trial.Turkish journal of physical medicine and rehabilitation · 2026Article
- Comparing the Effect of Subcutaneous and Intradermal Mesotherapy on Pain and Function in Knee Osteoarthritis: A Randomized Clinical Trial : Short title: Subcutaneous vs. Intradermal Mesotherapy in Knee Osteoarthritis.Galen medical journal · 2026Article
- A Retrospective Analysis of the Effectiveness and Safety of Collagen Mesotherapy in the Course of Chronic Cervical Myofascial Pain Syndrome.Biomedicines · 2025Article
- International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy: A Multidisciplinary Statement.Journal of clinical medicine · 2025Article
- Spinal collagen mesotherapy in patients with chronic thoracic back pain: a retrospective analysis of effectiveness and safety in a 3-month follow-up.Reumatologia · 2025Article
- The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain.Medeniyet medical journal · 2024Article
- Effects of intra-articular versus peri-articular dextrose prolotherapy in knee osteoarthritis: A clinical trial study.Turkish journal of physical medicine and rehabilitation · 2024Article
- Comparison of the Efficacy of Two Different Local Anesthesia Techniques for Mesotherapy in Temporal Region Alopecia.Cureus · 2024Article
- Efficacy and Safety of Spinal Collagen Mesotherapy in Patients with Chronic Low Back Pain in a Three-Month Follow-Up-Retrospective Study.Journal of clinical medicine · 2024Article
- Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain.Journal of personalized medicine · 2024Article
- Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy.Biomedicines · 2023Article
- Ultrasound Imaging and Guidance for Cervical Myofascial Pain: A Narrative Review.International journal of environmental research and public health · 2023Review
- Nociplastic Pain in Multiple Sclerosis Spasticity: Dermatomal Evaluation, Treatment with Intradermal Saline Injection and Outcomes Assessed by 3D Gait Analysis: Review and a Case Report.International journal of environmental research and public health · 2022Article
- A Call to Action by the Italian Mesotherapy Society on Scientific Research.Drug design, development and therapy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMesotherapy can be included as an ancillary treatment in the management of localized pain in rehabilitation, but there are no definitive treatment protocols for this approach.
objectivesThe purpose of this review was to examine new indications for more standard protocols of mesotherapy in rehabilitation. MATERIALS AND
methodsThis systematic review was performed using the following resources: PubMed, Cochrane, PEDro, Scopus, and Google Scholar. The following algorithm was developed, based on the PICO acronym, to evaluate the effects of mesotherapy, with pain as the primary outcome (MESH terms): [mesotherapy AND pain], [mesotherapy AND musculoskeletal], [mesotherapy AND musculoskeletal disorder], [intradermal therapy AND pain], and [intradermal therapy AND musculoskeletal disorder].
resultsSeven articles (N=7) satisfied the inclusion criteria and were considered in the review: two of them treated osteoarthritis of the knee (3 sessions) and pes anserine (9 sessions) emphasizing a good efficacy of mesotherapy. Five studies analyzed spine diseases (specifically, two was about chronic and nonspecific neck pain, two about acute low back pain and one about chronic spinal pain): the results of mesotherapy treatment are encouraging both for the resolution of acute and chronic musculoskeletal vertebral pain from one to five sessions.
conclusionMesotherapy showed a good effect to reduce acute and chronic musculoskeletal pain and, also, it is a well-tolerated treatment. Nonetheless future randomized controlled trials should be desirable for more uniform treatment protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.