ArticleVeterinary world2019
Comparison of biotechnological culture of hypoxia-conditioned rat mesenchymal stem cells with conventional
Article in Veterinary world, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- An Indonesian male with congenital hypogonadotropic hypogonadism: A case report and literature review.Annals of medicine and surgery (2012) · 2022Article
- The effect of mesenchymal stem cell-conditioned medium gel on burn wound healing in rat.Veterinary world · 2022Article
- Effectiveness of mesenchymal stem cells cultured under hypoxia to increase the fertility rate in rats (Veterinary world · 2021Article
- Effect of low oxygen tension on transcriptional factor OCT4 and SOX2 expression in New Zealand rabbit bone marrow-derived mesenchymal stem cells.Veterinary world · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimBiotechnological culture of hypoxia-conditioned (CH) rat mesenchymal stem cells (rMSC-CH) for testicular failure therapy with low libido improves the functional outcome of the testicle for producing spermatogenic cells and repairs Leydig cells in rats ( MATERIALS AND
methodsIn the first group (T1), rats with testicular failure and low libido were injected with normoxia-conditioned (CN) rMSCs (21% oxygen); in the second group (T2), rats with testicular failure and low libido were injected with rMSC-CH (1% oxygen); in the negative control group (T-), rats with normal testis were injected with 0.1 mL phosphate-buffered saline (PBS); and in the sham group (TS), rats with testicular failure and low libido were injected with 0.1 mL of PBS.
resultsVascular endothelial growth factor expression, as the homing signal, in the groups T2, T-, T1, and TS was 2.00±0.5%, 2.95±0.4%, 0.33±0.48%, and 0±0%, respectively. The number of cluster of differentiation (CD)34
conclusionrMSC-CH culture for testicular failure with low libido showed improvement in the functional outcome of the testicle and in repairing Leydig cells.
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