ArticleScientific reports2019
Acute exposure to a high-fat diet in juvenile male rats disrupts hippocampal-dependent memory and plasticity through glucocorticoids.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Effects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysis.BMJ open science · 2020Pooled it
- Brief high-fat diet exposure temporally reshapes affective behavior and prefrontal cortex function.bioRxiv : the preprint server for biology · 2026Article
- The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling.Nature communications · 2026Article
- Article
- Oxytocin agonist TGOT differentially modulates synaptic plasticity and intrinsic excitability in a sex-specific manner in the juvenile rat hippocampus.Communications biology · 2026Article
- Sex-dimorphic oxytocin regulation of CA1-dependent spatial memory and synaptic plasticity in juvenile rats.Behavioral and brain functions : BBF · 2025Article
- Review
- Article
- Western diet since adolescence impairs brain functional hyperemia at adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio.International journal of obesity (2005) · 2025Article
- High-fat Diet Coupled with Aerobic Exercise Has a Sexually Dimorphic Effect on the Biochemical Profile and Anxiety-like Behaviour of Adolescent Wistar Rats.Annals of neurosciences · 2025Article
- Feeding the hippocampus … with specific nutrients.Nature metabolism · 2025Article
- Differential response of the thyroid axis to high-fat diet-induced inflammation and energy balance deregulation in juvenile and adult rats.Frontiers in endocrinology · 2025Article
- Current status and trends in the study of intestinal flora in cognitive disorders: a bibliometric and visual analysis.Frontiers in microbiology · 2025Review
- High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice.Frontiers in nutrition · 2025Article
- Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut.Metabolic brain disease · 2024Article
- Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus.Biology of sex differences · 2024Article
- Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats.Pflugers Archiv : European journal of physiology · 2024Article
- Article
- Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.Appetite · 2024Article
- The Neuroprotective Role of Quinoa (Nutrients · 2024Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The limbic circuit is still undergoing maturation during juvenility and adolescence, explaining why environmental and metabolic challenges during these developmental periods can have specific adverse effects on cognitive functions. We have previously shown that long-term exposure (8-12 weeks) to high-fat diet (HFD) during adolescence (from weaning to adulthood), but not at adulthood, was associated with altered amygdala and hippocampal functions. Moreover, these HFD effects were normalized by treatment with glucocorticoid receptor (GR) antagonists. Here, we examined in male rats whether acute exposure (7-9 days) to HFD during juvenility [from postnatal day (PND) 21 to PND 28-30] or adulthood (from PND 60 to PND 67-69) is sufficient to affect hippocampal functions and whether it is also dependent on GRs activation. Juvenile HFD abolished both hippocampal synaptic plasticity, assessed through in vivo long-term potentiation (LTP) in CA1, and long-term hippocampal-dependent memory, using object location memory (OLM). No effect of HFD was observed in short-term OLM suggesting a specific effect on consolidation process. In contrast, adult HFD enhanced in vivo LTP and OLM. Systemic application of GR antagonist alleviated HFD-induced LTP and OLM impairments in juveniles. These results suggest that acute exposure to HFD during juvenility is sufficient to impair hippocampal functions in a GR-dependent manner. Interestingly, this effect depends on the developmental period studied as acute exposure to HFD at adulthood did not impair, but rather enhanced, hippocampal functions.
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