ArticleNature communications2019
Cortical reliability amid noise and chaos.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- Coding odor modality in piriform cortex efficiently with low-dimensional subspaces: a shared covariance decoding approach.Biological cybernetics · 2025Article
- Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects.Bioelectromagnetics · 2025Review
- Heterogeneous and higher-order cortical connectivity undergirds efficient, robust, and reliable neural codes.iScience · 2025Article
- Spike reliability is cell type specific and shapes excitation and inhibition in the cortex.Scientific reports · 2025Article
- Specific inhibition and disinhibition in the higher-order structure of a cortical connectome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Model-agnostic neural mean field with a data-driven transfer function.Neuromorphic computing and engineering · 2024Article
- Spike Reliability is Cell-Type Specific and Shapes Excitation and Inhibition in the Cortex.bioRxiv : the preprint server for biology · 2024Article
- Cortical cell assemblies and their underlying connectivity: An in silico study.PLoS computational biology · 2024Article
- Article
- Neurobiological Causal Models of Language Processing.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Mutual generation in neuronal activity across the brain via deep neural approach, and its network interpretation.Communications biology · 2023Article
- Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms.PLoS computational biology · 2023Article
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Consciousness is supported by near-critical slow cortical electrodynamics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Non-additive activity modulation during a decision making task involving tactic selection.Cognitive neurodynamics · 2022Article
- Topology of synaptic connectivity constrains neuronal stimulus representation, predicting two complementary coding strategies.PloS one · 2022Article
- Computational Concepts for Reconstructing and Simulating Brain Tissue.Advances in experimental medicine and biology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Typical responses of cortical neurons to identical sensory stimuli appear highly variable. It has thus been proposed that the cortex primarily uses a rate code. However, other studies have argued for spike-time coding under certain conditions. The potential role of spike-time coding is directly limited by the internally generated variability of cortical circuits, which remains largely unexplored. Here, we quantify this internally generated variability using a biophysical model of rat neocortical microcircuitry with biologically realistic noise sources. We find that stochastic neurotransmitter release is a critical component of internally generated variability, causing rapidly diverging, chaotic recurrent network dynamics. Surprisingly, the same nonlinear recurrent network dynamics can transiently overcome the chaos in response to weak feed-forward thalamocortical inputs, and support reliable spike times with millisecond precision. Our model shows that the noisy and chaotic network dynamics of recurrent cortical microcircuitry are compatible with stimulus-evoked, millisecond spike-time reliability, resolving a long-standing debate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.