Evidence map›Paper›PMID 31439762›Full record

ArticleScience (New York, N.Y.)2019

The Malaria Cell Atlas: Single parasite transcriptomes across the complete

Virginia M Howick, Andrew J C Russell, Tallulah Andrews, Haynes Heaton, Adam J Reid, Kedar Natarajan, Hellen Butungi, Tom Metcalf, Lisa H Verzier, Julian C Rayner and 6 more

Abstract readDataset
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed.

  1. An mRNA-lipid nanoparticle vaccine targeting theMolecular therapy. Nucleic acids · 2026
    Article
  2. Article
  3. Review
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  5. Article
  6. Article
  7. Article
  8. mSphere · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Single-cell analysis ofbioRxiv : the preprint server for biology · 2026
    Article
  15. Article
  16. Article
  17. Integrative genomics ofbioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Single-cell transcriptional changes of artemisinin-sensitive K13Frontiers in cellular and infection microbiology · 2026
    Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Virginia M HowickWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0003-3054-2460
Andrew J C RussellWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0001-5411-2807
Tallulah AndrewsWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0003-1120-2196
Haynes HeatonWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0002-9649-525X
Adam J ReidWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0002-5926-7768
Kedar NatarajanDanish Institute of Advanced Study (D-IAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-9264-1280
Hellen ButungiInternational Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.
Tom MetcalfWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Lisa H VerzierWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0002-5518-8157
Julian C RaynerWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0002-9835-1014
Matthew BerrimanWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0002-9581-0377
Jeremy K HerrenInternational Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.ORCID 0000-0003-2239-7275
Oliver BillkerWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0003-1716-168X
Martin HembergWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0001-8895-5239
Arthur M TalmanWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.ORCID 0000-0003-2584-3672
Mara K N LawniczakWellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. mara@sanger.ac.uk.ORCID 0000-0002-3006-2080

Funding

Large Scale systematic priorization of Plasmodium vivax blood stage vaccine antigensR01AI137154 · NIAID · UNIVERSITY OF CAMBRIDGE · PI RAYNER, JULIAN CHARLES · 2018 to 2021
$1.4M
Medical Research Council G1100339NIAID NIH HHS R01 AI137154Wellcome Trust 206194
6 · The paper itself

Abstract

Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire

Indexed as

Atlases as TopicTranscriptomeAnimalsAnophelesGenes, ProtozoanHeLa CellsHumansLife Cycle StagesMalariaPlasmodium bergheiSingle-Cell Analysis

Identifiers

PMID31439762
PMCPMC7056351

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.