Observational studyThe European respiratory journal2019
Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS.
Registry-linked trialAbstract readObservational Study
In one paragraph
Observational study in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence and Risk Factors for Progression from Pre-COPD to COPD: A Systematic Review and Meta‑analysis.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- Association of non-obstructive dyspnoea with all-cause mortality and incident chronic obstructive pulmonary disease: a systematic literature review and meta-analysis.BMJ open respiratory research · 2024Pooled it
- Effect of twice daily inhaled albuterol on cardiopulmonary exercise outcomes, dynamic hyperinflation, and symptoms in secondhand tobacco-exposed persons with preserved spirometry and air trapping: a randomized controlled trial.BMC pulmonary medicine · 2024Trial
- Plasma proteomic profiles of lung volume-based phenotypes in tobacco-exposed individuals without spirometric chronic obstructive pulmonary disease.Annals of the American Thoracic Society · 2026Observational
- Article
- Pre-COPD: Impact on prevention, detection, and treatment.Presse medicale (Paris, France : 1983) · 2026Review
- Physiological characteristics and temporal transitions of preserved ratio impaired spirometry.ERJ open research · 2026Article
- A Quantitative Lung Mucin Score to Identify Chronic Bronchitis.NEJM evidence · 2026Article
- Standard pulmonary function tests and respiratory oscillometry patterns in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis.BMJ open respiratory research · 2025Article
- Lung NR3C1Communications biology · 2025Article
- Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Lung Volumes in Smokers without Chronic Obstructive Pulmonary Disease: A Pointer to Disease Development?Annals of the American Thoracic Society · 2025Article
- Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes.Annals of the American Thoracic Society · 2025Article
- Preserved ratio impaired spirometry: clinical, imaging and artificial intelligence perspective.Journal of thoracic disease · 2025Review
- Association of Ground-Glass Opacities with Systemic Inflammation and Progression of Emphysema.American journal of respiratory and critical care medicine · 2024Article
- Symptoms of COPD in the absence of airflow obstruction are more indicative of pre-COPD than overdiagnosis.ERJ open research · 2024Article
- Impact of rapid iodine contrast agent infusion on tracheal diameter and lung volume in CT pulmonary angiography measured with deep learning-based algorithm.Japanese journal of radiology · 2024Article
- Chronic obstructive pulmonary disease (COPD) and COPD-like phenotypes.Frontiers in medicine · 2024Review
- Lung volumes differentiate the predominance of emphysemaERJ open research · 2023Article
Corrections and comments
- Commented on by
Authors and funding
24 authors.
Mehrdad ArjomandiSan Francisco Veterans Affairs Healthcare System, San Francisco, CA, USA mehrdad.arjomandi@ucsf.edu.
Siyang ZengSan Francisco Veterans Affairs Healthcare System, San Francisco, CA, USA.
Igor BarjaktarevicDept of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
R Graham BarrColumbia-Presbyterian Medical Center, New York, NY, USA.
Eugene R BleeckerUniversity of Arizona, College of Medicine, Tucson, AZ, USA.
Russell P BowlerNational Jewish Health Systems, Denver, CO, USA.
Russell G BuhrDept of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Gerard J CrinerTemple University, Philadelphia, PA, USA.
Alejandro P ComellasUniversity of Iowa, Iowa City, IA, USA.
Christopher B CooperDept of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
David J CouperUniversity of North Carolina, Chapel Hill, NC, USA.
Jeffrey L CurtisMedical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Mark T DransfieldUniversity of Alabama at Birmingham, Birmingham, AL, USA.
MeiLan K HanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Nadia N HanselJohns Hopkins Medical Institute, Baltimore, MD, USA.
Eric A HoffmanDept of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Robert J KanerWeill Cornell Weill Cornell Medical Center, New York, NY, USA.
Richard E KannerUniversity of Utah, Salt Lake City, UT, USA.
Jerry A KrishnanUniversity of Illinois at Chicago, Chicago, IL, USA.
Robert PaineUniversity of Utah, Salt Lake City, UT, USA.
Stephen P PetersWake Forest School of Medicine, Winston-Salem, NC, USA.
Stephen I RennardBioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Prescott G WoodruffDept of Medicine, University of California, San Francisco, CA, USA.
SPIROMICS Investigators
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MEarly Life Rhinovirus Infection and Childhood AsthmaR01AI120526 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2016 to 2024
$3.9MUltra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MCharacterizing the Respiratory Microbiome Via a Novel, Non-Invasive TechniqueR21AI117371 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ADAR, SARA · 2016 to 2017
$426kModulation of Steroid Suppression by Alveolar Macrophage EfferocytosisI01CX000911 · VA · VETERANS HEALTH ADMINISTRATION · PI CURTIS, JEFFREY LOUIS · 2016 to 2020
–CSRD VA I01 CX000911NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K24 HL137013NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIAID NIH HHS R01 AI120526NIAID NIH HHS R21 AI117371NIEHS NIH HHS P30 ES005605NIH HHS S10 OD018526
Abstract
The characteristics that predict progression to overt chronic obstructive pulmonary disease (COPD) in smokers without spirometric airflow obstruction are not clearly defined.We conducted a
Indexed as
AgedDisease ProgressionFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveResidual VolumeSmokingSpirometryTomography, X-Ray ComputedTotal Lung CapacityVital Capacity
Identifiers
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Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.