Evidence map›Paper›PMID 31439669›Full record

ArticleThe Journal of biological chemistry2019

The vault RNA of

Nikolay G Kolev, K Shanmugha Rajan, Kazimierz T Tycowski, Justin Y Toh, Huafang Shi, Yuling Lei, Shulamit Michaeli, Christian Tschudi

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nikolay G KolevDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut 06536 nikolay.kolev@yale.edu.
K Shanmugha RajanThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.
Kazimierz T TycowskiDepartment of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536.
Justin Y TohDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut 06536.
Huafang ShiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut 06536.
Yuling LeiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut 06536.
Shulamit MichaeliThe Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.
Christian TschudiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut 06536.ORCID 0000-0002-9365-5254
Yale University · USBar-Ilan University · ILHoward Hughes Medical Institute · US

Funding

TRANSCRIPTION AND RNA PROCESSING IN TRYPANOSOMESR01AI028798 · NIAID · YALE UNIVERSITY · PI TSCHUDI, CHRISTIAN · 1990 to 2020
$10.9M
Mechanism of Infectivity Acquisition in African TrypanosomesR01AI110325 · NIAID · YALE UNIVERSITY · PI TSCHUDI, CHRISTIAN · 2014 to 2023
$4.4M
RNA METABOLISM IN TRYPANOSOMESR37AI028798 · NIAID · YALE UNIVERSITY · PI ULLU, ELISABETTA · 2010 to 2013
$2.9M
NIAID NIH HHS R01 AI028798NIAID NIH HHS R01 AI110325NIAID NIH HHS R37 AI028798
6 · The paper itself

Abstract

The vault ribonucleoprotein (RNP), comprising vault RNA (vtRNA) and telomerase-associated protein 1 (TEP1), is found in many eukaryotes. However, previous studies of vtRNAs, for example in mammalian cells, have failed to reach a definitive conclusion about their function. vtRNAs are related to Y RNAs, which are complexed with Ro protein and influence Ro's function in noncoding RNA (ncRNA) quality control and processing. In

Indexed as

Base PairingBase SequenceCell NucleolusConserved SequenceDNA Polymerase IIIProtozoan ProteinsRNA InterferenceRNA, MessengerRNA, ProtozoanTranscription, GeneticTrans-SplicingTrypanosoma brucei bruceiVault Ribonucleoprotein ParticlesDNA Polymerase IIIProtozoan ProteinsRNA, MessengerRNA, ProtozoanVault Ribonucleoprotein ParticlesRNARNA-binding proteinRNA metabolismRNA processingRNA splicingRo proteinspliced leader (SL)telomerase-associated protein 1 (TEP1)Trypanosoma bruceivault RNA

Identifiers

PMID31439669
PMCPMC6816085
OpenAlexW2969302517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.