Evidence map›Paper›PMID 31439665›Full record

ArticleThe Journal of biological chemistry2019

17β-Estradiol nongenomically induces vascular endothelial H

Xingyan Xu, Qing Yan, Xiaoyun Liu, Ping Li, Xiaosa Li, Yiwen Chen, Tommaso Simoncini, Junxiu Liu, Dongxing Zhu, Xiaodong Fu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
  2. Crosstalk Between HHandbook of experimental pharmacology · 2026
    Review
  3. Review
  4. Review
  5. Posttranslational Regulation of Mammalian Sulfur Amino Acid Metabolism.International journal of molecular sciences · 2025
    Review
  6. The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Review
  7. Exploring the Mechanism of HInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Review
  16. Enhanced Sp1/YY1 Expression DirectsHypertension (Dallas, Tex. : 1979) · 2021
    Article
  17. Hydrogen Sulfide Actions in the Vasculature.Comprehensive Physiology · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Xingyan XuDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Qing YanDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Xiaoyun LiuDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Ping LiDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Xiaosa LiDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Yiwen ChenDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Tommaso SimonciniMolecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy.
Junxiu LiuDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China liujunxiu99@163.com.
Dongxing ZhuDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China dongxing.zhu@gzhmu.edu.cn.
Xiaodong FuDepartment of Gynecology and Obstetrics, The Sixth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China fuxiaod@mail.gzhmu.edu.cn.ORCID 0000-0003-2754-8976
State Key Laboratory of Respiratory Disease · CNSecond Affiliated Hospital of Guangzhou Medical University · CNSun Yat-sen University · CNUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen exerts its cardiovascular protective role at least in part by regulating endothelial hydrogen sulfide (H

Indexed as

Cyclic GMPCyclic GMP-Dependent Protein KinasesCystathionine gamma-LyaseEstradiolEstrogen Receptor alphaGenome, HumanGTP-Binding Protein alpha Subunits, Gi-GoGuanylate CyclaseHumansHuman Umbilical Vein Endothelial CellsHydrogen SulfideModels, BiologicalPhosphorylationProtein BindingSignal TransductionVasodilationCyclic GMPCyclic GMP-Dependent Protein KinasesCystathionine gamma-LyaseEstradiolEstrogen Receptor alphaGTP-Binding Protein alpha Subunits, Gi-GoGuanylate CyclaseHydrogen Sulfide17β-estradiolcell signalingcyclic GMP (cGMP)cystathionine γ-lyaseendothelial cellestrogengene regulationhydrogen sulfidenongenomic regulationprotein kinase G (PKG)sulfur metabolismvascular endothelial cellsvasodilationvasorelaxation

Identifiers

PMID31439665
PMCPMC6816087
OpenAlexW2969877657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.