Evidence map›Paper›PMID 31439663›Full record

ArticleThe Journal of biological chemistry2019

A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene

Mark B Meyer, Seong Min Lee, Alex H Carlson, Nancy A Benkusky, Martin Kaufmann, Glenville Jones, J Wesley Pike

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Systemic versus local regulation of vitamin D.Current opinion in nephrology and hypertension · 2026
    Review
  4. The Significance of Fibroblast Growth Factor 23 and 24,25-Dihydroxyvitamin D in Dent Disease Type 1.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  5. Article
  6. Review
  7. Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)The Journal of steroid biochemistry and molecular biology · 2025
    Article
  8. The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  9. Article
  10. bioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Renal proximal tubule cells: power and finesse.The Journal of clinical investigation · 2023
    Article
  17. Genomic mechanisms controlling renal vitamin D metabolism.The Journal of steroid biochemistry and molecular biology · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mark B MeyerDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.ORCID 0000-0001-6612-7491
Seong Min LeeDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Alex H CarlsonDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Nancy A BenkuskyDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706.
Martin KaufmannDepartment of Biomedical and Molecular Sciences, Queens University, Kingston, Ontario K7L 3N6, Canada.
Glenville JonesDepartment of Biomedical and Molecular Sciences, Queens University, Kingston, Ontario K7L 3N6, Canada.
J Wesley PikeDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 jpike@wisc.edu.
University of Wisconsin–Madison · USQueen's University · CA

Funding

Dynamic Mechanisms of Vitamin D-Induced Gene ExpressionR01DK072281 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2005 to 2012
$2.6M
Regulatory Mechanisms of Renal Vitamin D Activation and DegradationR01DK117475 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2018 to 2022
$2.0M
NIDDK NIH HHS R01 DK072281NIDDK NIH HHS R01 DK117475
6 · The paper itself

Abstract

Cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and CYP24A1 function to maintain physiological levels of 1,25-dihydroxyvitamin D

Indexed as

Response ElementsAnimalsCalcitriolChromatinCyclic AMP Response Element-Binding ProteinFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsKidneyMaleMiceMice, Inbred C57BLParathyroid HormoneReceptors, CalcitriolVitamin D3 24-HydroxylaseCalcitriolChromatinCyclic AMP Response Element-Binding ProteinCyp24a1 protein, mouseFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth FactorsParathyroid HormoneReceptors, CalcitriolVitamin D3 24-Hydroxylase1,25(OH)2D3ChIP-sequencing (ChIP-Seq)CRISPR/CasCyp24a1Cyp27b1Cyp27b1-KOcytochrome P450FGF23fibroblast growth factor (FGF)gene regulationparathyroid hormone (PTH)vitamin D

Identifiers

PMID31439663
PMCPMC6768633
OpenAlexW2969979551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.