Evidence map›Paper›PMID 31439661›Full record

ArticleHeart (British Cardiac Society)2020

Atrial fibrillation is not an independent predictor of outcome in patients with aortic stenosis.

Hongju Zhang, Edward A El-Am, Jeremy J Thaden, Sorin V Pislaru, Christopher G Scott, Chayakrit Krittanawong, Anwar A Chahal, Thomas J Breen, Mackram F Eleid, Rowlens M Melduni and 6 more

Open access · greenAbstract read
In one paragraph

Article in Heart (British Cardiac Society), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The impact of atrial fibrillation on prognosis in aortic stenosis.European heart journal. Quality of care & clinical outcomes · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Article
  11. Advances in the Treatment of Cardiac Amyloidosis.Current treatment options in oncology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Hongju ZhangDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Edward A El-AmDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Jeremy J ThadenDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Sorin V PislaruDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Christopher G ScottBiomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-1340-0647
Chayakrit KrittanawongDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Anwar A ChahalDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Thomas J BreenDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Mackram F EleidDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Rowlens M MelduniDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Kevin L GreasonDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, United States.
Robert B McCullyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Maurice Enriquez-SaranoDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Jae K OhDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Patricia A PellikkaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Vuyisile T NkomoDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States nkomo.vuyisile@mayo.edu.ORCID 0000-0001-6095-5579
Mayo Clinic · US

Funding

The Role of Autoimmune Mechanisms in the Pathogenesis of Atrial FibrillationK01HL135288 · NHLBI · MAYO CLINIC ROCHESTER · PI MELDUNI, ROWLENS MICHEL · 2017 to 2021
$854k
NHLBI NIH HHS K01 HL135288
6 · The paper itself

Abstract

objectivesTo examine the prognostic significance of atrial fibrillation (AF) versus sinus rhythm (SR) on the management and outcomes of patients with severe aortic stenosis (AS).

methods1847 consecutive patients with severe AS (aortic valve area ≤1.0 cm

resultsAge was 76±11 years and 46% were female; 293 (16%) patients had AF and 1554 (84%) had SR. In AF, 72% were symptomatic versus 71% in SR. Survival rate at 5 years for AF (41%) was lower than SR (65%) (age- and sex-adjusted HR=1.66 (1.40-1.98), p<0.0001). In multivariable analysis, factors associated with mortality included age (HR per 10 years=1.55 (1.42-1.69), p<0.0001), dyspnoea (HR=1.58 (1.33-1.87), p<0.0001), ≥ moderate mitral regurgitation (HR=1.63 (1.22-2.18), p=0.001), right ventricular systolic dysfunction (HR=1.88 (1.52-2.33), p<0.0001), left atrial volume index (HR per 10 mL/m

conclusionAF was associated with poor prognosis in patients with severe AS, but apparent differences in outcomes compared with SR were explained by factors other than AF including concomitant cardiac abnormalities and deferral of AVR due to attribution of cardiac symptoms to AF.

Indexed as

MortalityAgedAged, 80 and overAge FactorsAortic Valve StenosisAtrial FibrillationBioprosthesisCardiovascular DiseasesCause of DeathComorbidityConservative TreatmentDyspneaEchocardiography, DopplerFemaleHeart FailureHeart Valve Prosthesisaortic stenosisaortic valve replacementatrial fibrillationmortalitynatural historyprognosis

Identifiers

PMID31439661
PMCPMC6989366
OpenAlexW2969335174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.